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Functional analysis of tight junctions
Methods, 2003Epithelial and endothelial cells are joined to each other via a set of intercellular junctions that differ in their morphological appearance, composition, and function. The tight junction or zonula occludens is the intercellular junction that regulates diffusion between cells and therefore allows endothelia and epithelia to form cellular barriers that ...
Karl, Matter, Maria S, Balda
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Tight Junctions and Gap Junctions
2010Tight junctions have several major functions. They seal the intercellular space in epithelial and endothelial cell layers and prevent free paracellular passage of substances. They determine the polarity of epithelial cells by creating a boundary between the apical domain of the plasma membrane and the basolateral domain and prevent diffusion of lipids ...
Margit Pavelka, Jürgen Roth
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Perspectives on tight junction research
Annals of the New York Academy of Sciences, 2012The tight junction connects neighboring epithelial or endothelial cells. As a general function, it seals the paracellular pathway and thus prevents back‐leakage of just transported solutes and water. However, not all tight junctions are merely tight: some tight junction proteins build their own transport pathways by forming channels selective for small
Jörg-Dieter, Schulzke +3 more
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The molecular structure of the tight junction
Advanced Drug Delivery Reviews, 2000The maintenance of a barrier with controlled permeability is an important characteristic for multi-cellular organisms. In mammalian cells, the tight junction functions in that role allowing compartments with different solute composition to be separate, but not absolutely unconnected.
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Tight junctions: from simple barriers to multifunctional molecular gates
Nature Reviews Molecular Cell Biology, 2016Ceniz Zihni, Clare Mills, Karl Matter
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Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow
Cell, 2019Alexandra Schauer +2 more
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