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American Review of Respiratory Disease, 1988
Abstract Epithelial cells differentiate by polarizing into an apical and a basolateral domain and by forming tight junctions (TJ) that control permeation through the paracellular route. The molecular nature of this structure, as well as the processes of assembly, sealing, and regulation, are not yet fully understood.
M, Cereijido +2 more
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Abstract Epithelial cells differentiate by polarizing into an apical and a basolateral domain and by forming tight junctions (TJ) that control permeation through the paracellular route. The molecular nature of this structure, as well as the processes of assembly, sealing, and regulation, are not yet fully understood.
M, Cereijido +2 more
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Tight junctions of oligodendrocytes
Cell and Tissue Research, 1977Freeze-fracture replicas of the rat corpus callosum revealed prominent junctional strands in fractured cell membranes of the somata of oligodendrocytes. The junctional strands were characterized by an elaborate system of straight or slightly undulating rows of linear aggregates of particles or ridges in the P face and furrows in the E face.
E, Tani, T, Itagaki, M, Nakano
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Tight junctions: from simple barriers to multifunctional molecular gates [PDF]
Nature Reviews Molecular Cell Biology, 2016 Epithelia and endothelia separate different tissue compartments and protect multicellular organisms from the outside world. This requires the formation of tight junctions, selective gates that control paracellular diffusion of ions and solutes.
Karl Matter, Ceniz Zihni, Maria S. Balda
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The making of a tight junction
Journal of Cell Science, 1993ABSTRACT MDCK (epithelial cells from the dog kidney) plated at confluence, establish tight junctions in 12-15 hours through a process that requires protein synthesis, formation of a ring of actin filaments in close contact with the lateral membrane of the cells, calmodulin, and a Ca2+-dependent exocytic fusion of tight junction (TJ ...
M, Cereijido +5 more
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Cell, 1982
We have analyzed previous thin-section and freeze-fracture observations of the tight junction. We propose that the tight-junction strands represent intramembranous, cylindrical, inverted micelles. At the junctional site, the exoplasmic halves of the plasma membranes are fused into a continuous leaflet.
P, Pinto da Silva, B, Kachar
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We have analyzed previous thin-section and freeze-fracture observations of the tight junction. We propose that the tight-junction strands represent intramembranous, cylindrical, inverted micelles. At the junctional site, the exoplasmic halves of the plasma membranes are fused into a continuous leaflet.
P, Pinto da Silva, B, Kachar
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Transmembrane proteins of tight junctions [PDF]
Biochimica Et Biophysica Acta - Biomembranes, 2008 Tight junctions contribute to the paracellular barrier, the fence dividing plasma membranes, and signal transduction, acting as a multifunctional complex in vertebrate epithelial and endothelial cells.
Makoto Osanai +2 more
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Tight junctions and tight junction proteins in mammalian epidermis
European Journal of Pharmaceutics and Biopharmaceutics, 2009Tight junctions (TJ) are barrier forming cell-cell junctions that are found in a variety of cell types and tissues but their existence in mammalian epidermis has been shown only in the last years. A variety of TJ proteins were identified in mammalian epidermis, comprising several members of the claudin family, occludin, and JAM-A as well as ZO-1 and ...
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Annals of the New York Academy of Sciences, 2009
Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically “seal” the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial surfaces of different tightness ...
Jörg‐Dieter Schulzke, Michael Fromm
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Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically “seal” the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial surfaces of different tightness ...
Jörg‐Dieter Schulzke, Michael Fromm
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Tight Junctions and Cell Polarity
Annual Review of Cell and Developmental Biology, 2006The tight junction is an intracellular junctional structure that mediates adhesion between epithelial cells and is required for epithelial cell function. Tight junctions control paracellular permeability across epithelial cell sheets and also serve as a barrier to intramembrane diffusion of components between a cell's apical and basolateral membrane ...
Kunyoo Shin, Ben Margolis
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THE TIGHT JUNCTION: Morphology to Molecules
Annual Review of Cell and Developmental Biology, 1998▪ Abstract The tight junction forms a regulated barrier in the paracellular pathway between epithelial and endothelial cells. This intercellular junction also demarcates the compositionally distinct apical and basolateral membranes. While the existence of a paracellular barrier in epithelia was hypothesized by physiologists over a century ago, the ...
B R, Stevenson, B H, Keon
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