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Signalling to and from tight junctions
Nature Reviews Molecular Cell Biology, 2003Tight junctions have long been regarded as simple barriers that separate compartments of different compositions, but recent research indicates that different types of signalling proteins and transduction pathways are associated with these junctions. They receive and convert signals from the cell interior to regulate junction assembly and function, and ...
Karl, Matter, Maria S, Balda
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Tight Junctions and Gap Junctions
2010Tight junctions have several major functions. They seal the intercellular space in epithelial and endothelial cell layers and prevent free paracellular passage of substances. They determine the polarity of epithelial cells by creating a boundary between the apical domain of the plasma membrane and the basolateral domain and prevent diffusion of lipids ...
Margit Pavelka, Jürgen Roth
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MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS
Annual Review of Physiology, 1998▪ Abstract The tight junction creates a regulated barrier in the paracellular pathway and, together with the actin-rich adherens junction, forms a functional unit called the apical junction complex. A growing number of tight junction–associated proteins have been identified, but functions are defined for only a few.
L L, Mitic, J M, Anderson
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Occldin and the Functions of Tight Junctions
1998The tight junction or zonula occludens is the most apical structure of the epithelial junctional complex. Tight junctions from semipermeable intercellular diffusion barriers that control paracellular diffusion in a regulated manner. This intercellular junction also acts as an intramembrane fence that prevents the intermixing of apical and basolateral ...
Matter K, Balda MS
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The molecular structure of the tight junction
Advanced Drug Delivery Reviews, 2000The maintenance of a barrier with controlled permeability is an important characteristic for multi-cellular organisms. In mammalian cells, the tight junction functions in that role allowing compartments with different solute composition to be separate, but not absolutely unconnected.
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Target specific tight junction modulators
Advanced Drug Delivery Reviews, 2021Gerrit Borchard, Joel Brunner
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Tight Junction Structure and Function Revisited
Trends in Cell Biology, 2020Tetsuhisa Otani, Mikio Furuse
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CPEB gets tight with junctions
Nature Reviews Molecular Cell Biology, 2012Maria Papatriantafyllou
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