Results 181 to 190 of about 27,271 (263)

Decidual CD4 Effector Memory and Resident Memory T Cells Respond to Cord Blood Allo‐Antigens

American Journal of Reproductive Immunology, Volume 95, Issue 2, February 2026.
ABSTRACT Problem Maternal CD4 T cells are critical coordinators of maternal–fetal immune tolerance and immunity during pregnancy. Decidual regulatory T cells (TREG) have been shown to provide essential immune suppressive functions to control allogeneic responses and inflammation.
Zachary T. Koenig, Shruti Eswar, Sayaka Tsuda, Nathan Schuldt, Claire A. Chougnet, Braxton Forde, Sandra Andorf, Tamara Tilburgs   +7 more
wiley   +1 more source

Enhancing anti-tumor immunity through co-blocking PD-L1 and TIGIT by facilitating tumor-directed responses and additional VEGF inhibition. [PDF]

Front Immunol
Zhu X, Cui X, Yu H, Xu J, Chen X, Ren X, Wei X, Chen S, Wang Y, Fei L, Xie B, Li M, Li X, Jia H, Feng Y, Xia S, Chen L, Cheng Y, Zhang L, Li H, Zhu X, Zhan Y.   +21 more
europepmc   +1 more source

TIGIT-targeting Agent MK-7684 [PDF]

, 2020
openaire   +1 more source

Prognostic Impact of DPP4 Inhibitors on Systemic Drug Therapy for Advanced Kidney Cancer Patients

Cancer Science, Volume 117, Issue 2, Page 468-475, February 2026.
Treatment with DPP4 inhibitors was identified as a favorable prognostic factor in patients with advanced RCC. A more substantial degree of tumor shrinkage was observed in the subgroup of patients who received tyrosine kinase inhibitors or immune checkpoint inhibitors as first‐line therapy.
Shuhei Kamada, Sachi Kitayama, Ryosuke Yamase, Kazuhiro Ikeda, Wataru Sato, Tomokazu Sazuka, Hideki Takeshita, Shinichi Sakamoto, Akihiro Yano, Kuniko Horie, Tomohiko Ichikawa, Satoru Kawakami, Satoshi Inoue   +12 more
wiley   +1 more source

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

Targeting T cell exhaustion in colorectal cancer: emerging roles of LAG-3, TIM-3, and TIGIT signaling in overcoming immunotherapy resistance. [PDF]

Cell Commun Signal
Zamani P, Barootchi E, Firouzabadi A, Tonekaboni MS, Saleki K, Yazdanpanah N, Rezaei N.   +6 more
europepmc   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

Preclinical evaluation of TIGIT as a target to enhance efficacy and mitigate T cell exhaustion in multiple myeloma following BCMA-CAR-T therapy. [PDF]

Cell Death Dis
Xia Y, Zhu J, Guo R, Shen X, Shi M, Shen N, Fan L, Chen L.   +7 more
europepmc   +1 more source

Curcumin Modulates TIGIT/Neuropilin-1 to Regulate T-Cell Immune Homeostasis in Ulcerative Colitis. [PDF]

Foods
Liu Y, Huang J, Yu J, Fu L, Huang R, Liu J, Deng B, Zhong YB, Liu D, Zhao H.   +9 more
europepmc   +1 more source

Anti-TIGIT Monoclonal Antibody AB154 [PDF]

, 2020
openaire   +1 more source