Results 231 to 240 of about 27,271 (263)

Differentiated Thyroid Cancer Is Associated With Sex-specific Immune Response. [PDF]

J Endocr Soc
Shobab L, Simpson J, McCoy M, Zheng H, Kumari S, Fan R, Budd S, Lee W, Rosen J, Vasko V, Wartofsky L, Brenchley JM, Atkins MB, Klubo-Gwiezdzinska J, Burman KD.   +14 more
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Erratum: Predicting prognosis in lung adenocarcinoma by predicting TIGIT expression: a pathomics model. [PDF]

J Thorac Dis
Editorial Office.
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Beyond monotherapy: multimodal strategies integrating immune checkpoint inhibitors in lymphoma management. [PDF]

Front Immunol
Li Y, Zheng R, Pan B, Wang X, Zhang L, Gao H, Li L.   +6 more
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Multidimensional plasticity of natural killer cells in tumours. [PDF]

Cell Death Dis
Yang X, Song Z, Chen L, Jia Q, Li M.
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Iron Deficiency Drives Th2-Mediated Immunity in Pediatric Atopic Dermatitis Through DNA Hypermethylation and TIGIT Suppression in IL-10-Producing Breg Cells. [PDF]

J Asthma Allergy
Gao X, Hou Z, Li X, Ouyang T, Yu S, Wang Y, Zhang G, Luo Y, He X, Liao W, Wei Z.   +10 more
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Immunotherapy in clear cell renal cell carcinoma: current Status, novel Strategies, and future perspectives. [PDF]

Clin Exp Med
Chen X, Ke Y, Huang X, Chen J, Chen J, Chen Z.   +5 more
europepmc   +1 more source

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TIGIT-Fc Promotes Antitumor Immunity

Cancer Immunology Research, 2021
Abstract T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a checkpoint receptor that mediates both T-cell and natural killer (NK)–cell exhaustion in tumors. An Fc-TIGIT fusion protein was shown to induce an immune-tolerance effect in a previous report, but the relevance of the TIGIT ...
Xian, Shen, Wenyan, Fu, Yongpeng, Wei, Junle, Zhu, Yue, Yu, Changhai, Lei, Jian, Zhao, Shi, Hu   +7 more
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TIGIT limits immune pathology during viral infections [PDF]

Nature Communications, 2020
AbstractCo-inhibitory pathways have a fundamental function in regulating T cell responses and control the balance between promoting efficient effector functions and restricting immune pathology. The TIGIT pathway has been implicated in promoting T cell dysfunction in chronic viral infection.
Michelle Schorer, Katharina Lambert, Annika Hunziker   +2 more
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Abstract 5421: Prediction of intratumoral TIGIT receptor occupancy after the treatment with anti-TIGIT antibodies

Cancer Research, 2022
Abstract Background: T-cell immunoreceptor with immunoglobulin and tyrosine based inhibitory motif domain (TIGIT) is a co-inhibitory immune checkpoint receptor expressed on several types of immune cells, which can suppress T-cell activation, promote T-cell exhaustion, and suppress natural killer cell mediated cytotoxicity.
Dmitry Shchelokov, Oleg Demin, Oleg Demin, Ahsan Rizwan, Yun Zhang, Wei Tan, Srikumar Sahasranaman, Nageshwar Budha   +7 more
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Tiragolumab Results Cast Shadow on TIGIT Pipeline

Cancer Discovery, 2022
Abstract Genentech's TIGIT-targeted antibody tiragolumab missed its endpoints in two late-stage lung cancer trials, raising doubts about one of the most widely studied next-generation checkpoint targets in immuno-oncology. But numerical signs of benefit among certain patients with metastatic non–small cell lung cancer suggest that TIGIT ...
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