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TIGIT mediated T cell exhaustion in cancer is dependent on TIGIT/CD226 interaction (TUM2P.907)
The Journal of Immunology, 2014Abstract The generation of blocking antibodies against co-inhibitory receptors involved in T cell exhaustion is a recent key strategy for cancer immunotherapy. We have shown that co-blockade of TIGIT and PD-L1 results in tumor rejection by restoring the function of exhausted tumor-infiltrating CD8+ T cells.
Laetitia Comps-Agrar +7 more
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TIGIT, A Novel Therapeutic Target for Tumor Immunotherapy
Immunological Investigations, 2016Co-inhibitory and co-stimulatory receptors act in concert to regulate adaptive immune cell function, and the balance of these receptors is essential for the maintenance of immune homeostasis. Tumors constitute highly suppressive microenvironments in which elevated expression of co-inhibitory receptors on tumor-infiltrating lymphocytes (TILs) is often ...
Xin-Guang, Liu, Ming, Hou, Yu, Liu
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TIGIT: A potential immunotherapy target for gynecological cancers
Pathology - Research and PracticeGynecological cancer represents a significant global health challenge, and conventional treatment modalities have demonstrated limited efficacy. However, recent investigations into immune checkpoint pathways have unveiled promising opportunities for enhancing the prognosis of patients with cancer.
Siyue, Jiang +2 more
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TIGIT therapy for cancer treatment
2018Treating tumors with immune-related therapies is one of the most exciting and promising advancements made in the past decade. Cancer immunotherapy drugs have captured nearly 50% of the overall oncology drugs market. TIGIT is an important checkpoint inhibitory receptor discovered by our group in 2009.
Mandelboim, Ofer +3 more
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Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways
Nature Reviews Clinical Oncology, 2021Lukas Kraehenbuehl +2 more
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497 Evaluation of the TIGIT+ immune subset depletion effect of the anti-TIGIT antibody M6223
Regular and Young Investigator Award Abstracts, 2022Chunxiao Xu +5 more
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Transcriptome Profiling Identifies TIGIT as a Marker of T‐Cell Exhaustion in Liver Cancer
Hepatology, 2021Norman Woller +2 more
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TIGIT as an emerging immune checkpoint
Clinical and Experimental Immunology, 2020Camille Guillerey
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