Results 21 to 30 of about 17,630,315 (317)

TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. [PDF]

PLoS ONE, 2012
T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted CD8(+) T cells in both chronic infection and tumor. However, the nature of TIM-3(+)CD4(
Xin Gao, Yibei Zhu, Gang Li, Haitao Huang, Guangbo Zhang, Fengming Wang, Jing Sun, Qianting Yang, Xueguang Zhang, Binfeng Lu   +9 more
doaj   +1 more source

Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. [PDF]

, 2020
Although immunotherapies have achieved remarkable salutary effects among subgroups of advanced cancers, most patients do not respond. We comprehensively evaluated biomarkers associated with the "cancer-immunity cycle" in the pan-cancer setting in order ...
Dressman, Devin, Eskander, Ramez, Glenn, Sean T, Goodman, Aaron, Ikeda, Sadakatsu, Kato, Shumei, Kumaki, Yuichi, Kurzrock, Razelle, Lee, Suzanna, Lenzo, Felicia L, Morrison, Carl, Nikanjam, Mina, Okamura, Ryosuke, Papanicolau-Sengos, Antonios   +13 more
core   +1 more source

Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway. [PDF]

PLoS ONE, 2016
NK cells accumulate at the maternal-fetal interface (MFI) and play essential roles in maintaining immune tolerance during pregnancy. The mechanisms that facilitate NK cells tolerance to fetal tissue are largely unknown.
Jintang Sun, Meixiang Yang, Yanli Ban, Wenjuan Gao, Bingfeng Song, Yang Wang, Yun Zhang, Qianqian Shao, Beihua Kong, Xun Qu   +9 more
doaj   +1 more source

Expression of inhibitory receptors PD-1, CTLA-4, and Tim-3 by peripheral T cells during pregnancy

Бюллетень сибирской медицины, 2022
Background. Inhibitory receptors and their ligands (also called checkpoint molecules) are important feedback regulators of the immune response. However, their role in immunological adaptation during pregnancy remains poorly understood.The aim of the ...
E. A. Smetanenko, N. A. Khonina, O. Yu. Leplina, M. A. Tikhonova, E. V. Batorov, N. M. Pasman, E. R. Chernykh   +6 more
doaj   +1 more source

TIM-3 as a Prognostic Marker and a Potential Immunotherapy Target in Human Malignant Tumors: A Meta-Analysis and Bioinformatics Validation

Frontiers in Oncology, 2021
BackgroundAs a novel immune checkpoint molecular, T-cell immunoglobulin mucin 3 (TIM-3) is emerging as a therapeutic target for cancer immunotherapy. However, the predictive role of TIM-3 in cancer remains largely undetermined. This study was designed to
Kui Zang, Liangliang Hui, Min Wang, Ying Huang, Xingxing Zhu, Bin Yao   +5 more
doaj   +1 more source

TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors

Cancer Immunology and Immunotherapy, 2023
T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been a trending topic in recent years due to its differential expression in a wide range of neoplasms.
N. Sauer, N. Janicka, W. Szlasa, Bartłomiej Skinderowicz, Katarzyna Kołodzińska, W. Dwernicka, Małgorzata Oślizło, J. Kulbacka, V. Novickij, K. Karłowicz-Bodalska   +9 more
semanticscholar   +1 more source

Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells [PDF]

, 2015
The T cell immunoglobulin and mucin domain 3 (Tim-3) is a plasma membrane-associated receptor which is involved in a variety of biological responses in human immune cells.
Bardelli, Marco, Gibbs, Bernhard F, Goncalves Silva, Isabel, Sumbayev, Vadim V., Varani, Luca   +4 more
core   +2 more sources

Tim-3+ decidual Mφs induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance via CD132

Cell Death and Disease, 2022
T-cell immunoglobulin mucin-3 (Tim-3) plays roles in the functional regulation of both adaptive and innate immune cells and is greatly involved in many diseases. However, the precise roles of Tim-3 on macrophages (Mφs) in pregnancy remain unstated.
Mengdie Li, Fengrun Sun, Yuanyuan Xu, Lanting Chen, Chunqin Chen, Liyuan Cui, Jinfeng Qian, Dajin Li, Songcun Wang, Meirong Du   +9 more
doaj   +1 more source

Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients [PDF]

, 2019
Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach; however, it has shown limited success in some cancers including colorectal cancer (CRC). The tumor microenvironment (TME) is largely responsible for response to therapy,
Abu Nada, M, Al-Dhaheri, M, Elkord, E, Khawar, M, Murshed, K, Toor, SM   +5 more
core   +2 more sources

Tim-3-expressing CD4+ and CD8+ T cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions.

PLoS Pathogens, 2012
T-cell immune responses modulated by T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) during Mycobacterium tuberculosis (Mtb) infection in humans remain poorly understood.
Yueqin Qiu, Jianbo Chen, Hongying Liao, Yan Zhang, Hua Wang, Shaoyuan Li, Yanfen Luo, Danyun Fang, Guobao Li, Boping Zhou, Ling Shen, Crystal Y Chen, Dan Huang, Jiye Cai, Kaiyuan Cao, Lifang Jiang, Gucheng Zeng, Zheng W Chen   +17 more
doaj   +1 more source