Results 11 to 20 of about 36,815 (253)
Microfluidics: From crystallization to serial time-resolved crystallography [PDF]
Structural Dynamics, 2017 Capturing protein structural dynamics in real-time has tremendous potential in elucidating biological functions and providing information for structure-based drug design.
Shuo Sui, Sarah L. Perry
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Crystals, 2022 This Special Issue on ‘Time-Resolved Crystallography’ is a collection of eight original articles providing interesting results that give insight into the processes involved in generating and analysing time-resolved data [...]
Connie Darmanin
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Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection [PDF]
IUCrJ, 2021 Time-resolved crystallography of biomolecules in action has advanced rapidly as methods for serial crystallography have improved, but the large number of crystals and the complex experimental infrastructure that are required remain serious obstacles to ...
Jonathan A. Clinger +4 more
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A tool for visualizing protein motions in time-resolved crystallography [PDF]
Structural Dynamics, 2020 Time-resolved serial femtosecond crystallography (TR-SFX) at an x-ray free electron laser enables protein structural changes to be imaged on time-scales from femtoseconds to seconds.
Cecilia Wickstrand +6 more
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Droplet microfluidics for time-resolved serial crystallography [PDF]
IUCrJSerial crystallography requires large numbers of microcrystals and robust strategies to rapidly apply substrates to initiate reactions in time-resolved studies.
Jack Stubbs +13 more
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Best practices for time-resolved serial synchrotron crystallography [PDF]
Acta Crystallographica Section D: Structural Biology, 2022 With recent developments in X-ray sources, instrumentation and data-analysis tools, time-resolved crystallographic experiments, which were originally the preserve of a few expert groups, are becoming simpler and can be carried out at more radiation sources, and are thus increasingly accessible to a growing user base. However, these experiments are just
Eike C Schulz +2 more
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Advances and challenges in time-resolved macromolecular crystallography
Science, 2021 Bright future ahead for crystallography Macromolecular x-ray crystallography typically provides static snapshots of systems at equilibrium. Advances in time-resolved crystallography have made it possible to capture dynamics in biomolecules: large and small, fast and slow.
Gisela Branden, Richard Neutze
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Laue diffraction and time-resolved crystallography: a personal history. [PDF]
Philos Trans A Math Phys Eng Sci, 2019 A personal, historical view is presented of Laue X-ray diffraction and its application to time-resolved studies of dynamic processes, largely in light-sensitive biological systems. In Laue diffraction, a stationary crystal is illuminated by a polychromatic X-ray source.
Moffat K.
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Crystals, 2021 The ultrabright and ultrashort pulses produced at X-ray free electron lasers (XFELs) has enabled studies of crystallized molecular machines at work under ‘native’ conditions at room temperature by the so-called time-resolved serial femtosecond ...
Jose M. Martin-Garcia
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Time-Resolved Macromolecular Crystallography Frontiers at BioCARS: Serial Laue Micro-Crystallography and Electric Field Jump [PDF]
Structural DynamicsBioCARS is a University of Chicago National User Facility with more than 25 years of scientific focus on synchrotron-based, dynamic studies in structural biology, initially using time-resolved protein crystallography and, more recently, time-resolved ...
Robert Henning +5 more
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