Results 41 to 50 of about 36,815 (253)
Following replicative DNA synthesis by time-resolved X-ray crystallography
Nature Communications, 2021 DNA polymerases are the key enzymes responsible for DNA replication and repair. Here the authors reveal through time-lapsed images of X-ray crystal structures that translocation precedes phosphodiester bond formation in the mechanism of DNA synthesis.
Nicholas Chim +4 more
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eLife, 2021 Channelrhodopsins (ChRs) are microbial light-gated ion channels utilized in optogenetics to control neural activity with light . Light absorption causes retinal chromophore isomerization and subsequent protein conformational changes visualized as ...
Kazumasa Oda +47 more
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Time-Resolved Macromolecular Crystallography [PDF]
Physics Today, 2001 Rapid x-ray characterization of structure and innovative ways of initiating and controlling reactions are shedding new light on protein function by enabling the visualization of macromolecules in action.
Eric A. Galburt, Barry L. Stoddard
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Approach of Serial Crystallography II
Crystals, 2021 Serial crystallography (SX) is an emerging X-ray crystallographic method for determining macromolecule structures. It can address concerns regarding the limitations of data collected by conventional crystallography techniques, which require cryogenic ...
Ki-Hyun Nam
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Time-Resolved Macromolecular Crystallography [PDF]
Annual Review of Biophysics and Biophysical Chemistry, 1989 Reaction mechanisms in chemistry and biochemistry involve structural change, not merely static structure (1). These structural changes can be very rapid, spanning the time range from femtoseconds to seconds and above. We have developed and applied timeresolved X-ray crystallography(2,3) to monitor directly the changes in electron density and hence in ...
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Sample Preparation for Time-Resolved Serial Crystallography: Practical Considerations
, 2023 Time-resolved serial crystallography is an emerging method to elucidate the structure-function relationship of biomolecular systems at up to atomic resolution.
Mehrabi, P., Schulz, E.
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Ring closing reaction in diarylethene captured by femtosecond electron crystallography [PDF]
, 2013 The photoinduced ring closing reaction in diarylethene, which serves as a modelsystem for understanding reactive crossings through conical intersections, was directly observed with atomic resolution using femtosecond electron diffraction.
Liu, Lai Chung +15 more
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Structural characterization of electron transfer in D.m (6-4) photolyase by time-resolved X-ray crystallography [PDF]
, 2022 Photolyases are flavoproteins widely spread in bacteria, archea, fungi, plants and animals. These enzymes absorb blue light and use it as an energy source for repairing damages that are induced on DNA after a prolonged exposure to UV-light. The mechanism
Cellini, Andrea
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Time Resolved Diffraction Studies of Structural Changes in Sensory Rhodopsin [PDF]
, 2019 Responding to different light conditions is an essential process for many organisms on earth. Unicellular organisms are no exception to this and mechanisms for controlling cellular movement must often be sensitive to light.
Bosman, Robert
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High-throughput high-resolution cryo-electron crystallography [PDF]
, 2015 High-resolution structures of membrane and soluble proteins can be obtained by cryo-electron crystallography, given highly-ordered cryo-preparations of perfectly flat 2D crystals are available.
Scherer, Sebastian
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