Results 51 to 60 of about 197,559 (298)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
5 ps Jitter Programmable Time Interval/Frequency Generator
Metrology and Measurement Systems, 2017 A new time interval/frequency generator with a jitter below 5 ps is described. The time interval generation mechanism is based on a phase shifting method with the use of a precise DDS synthesizer. The output pulses are produced in a Spartan-6 FPGA device,
Kwiatkowski Paweł +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
A 0.002‐mm2 8‐bit 1‐MS/s low‐power time‐based DAC (T‐DAC)
IET Circuits, Devices and Systems, 2021 Digital‐to‐analogue converters (DACs) are essential blocks for interfacing the digital environment with the real world. A novel architecture, using a digital‐to‐time converter (DTC) and a time‐to‐voltage converter (TVC), is employed to form a low‐power ...
Ali H. Hassan +4 more
doaj +1 more source
Phase–frequency detecting time-to-digital converter
Electronics Letters, 2009 A simple time-to-digital converter (TDC), capable of detecting not only phase difference but also frequency difference, is presented. The proposed TDC guarantees pull-in even for PLLs with the lowest loop gain. The TDC is fabricated in a 65 nm CMOS process and dissipates 0.37 mW from a 1.2 V supply at 25 MHz clock frequency.
D.-H. Oh, K.-J. Choo, D.-K. Jeong
openaire +1 more source
Special Considerations in Estate Planning for Same-Sex and Unmarried Couples [PDF]
, 2013 Sub-Nyquist sampling makes use of sparsities in analog signals to sample them at a rate lower than the Nyquist rate. The reduction in sampling rate, however, comes at the cost of additional digital signal processing (DSP) which is required to reconstruct
Johansson, Håkan +1 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Digital twin based monitoring and control for DC-DC converters
Nature Communications, 2023 The monitoring and control of DC-DC converters have become key issues since DC-DC converters are gradually playing increasingly crucial roles in power electronics applications such as electric vehicles and renewable energy systems.
Zhongcheng Lei +4 more
doaj +1 more source
Variation Resilient Adaptive Controller for Subthreshold Circuits
, 2009 Subthreshold logic is showing good promise as a viable ultra-low-power circuit design technique for power-limited applications. For this design technique to gain widespread adoption, one of the most pressing concerns is how to improve the robustness of ...
Al-Hashimi, Bashir +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source