Results 31 to 40 of about 30,664 (252)

A Digital PLL with a Stochastic Time-to-Digital Converter [PDF]

2006 Symposium on VLSI Circuits, 2006. Digest of Technical Papers., 2006
A new dual-loop digital phase-locked loop (DPLL) architecture is presented. It employs a stochastic time-to-digital converter (STDC) and a high-frequency delta-sigma dithering to achieve wide PLL bandwidth and low jitter at the same time. The STDC exploits the stochastic properties of a set of latches to achieve high resolution.
Volodymyr Kratyuk, Pavan Kumar Hanumolu, Kerem Ok, Un-Ku Moon, Kartikeya Mayaram   +4 more
openaire   +1 more source

Low-Resource Time-to-Digital Converters for Field Programmable Gate Arrays: A Review

Sensors
A fundamental aspect in the evolution of Time-to-Digital Converters (TDCs) implemented within Field-Programmable Gate Arrays (FPGAs), given the increasing demand for detection channels, is the optimization of resource utilization.
Diego Real, David Calvo
doaj   +1 more source

Underwater Single-Photon Lidar Equipped with High-Sampling-Rate Multi-Channel Data Acquisition System

Remote Sensing, 2023
Lidar has emerged as an important technology for the high-precision three-dimensional remote sensing of the ocean. While oceanic lidar has been widely deployed on various platforms, its underwater deployment is relatively limited, despite its ...
Zaifa Lin, Mingjia Shangguan, Fuqing Cao, Zhifeng Yang, Ying Qiu, Zhenwu Weng   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Time-to-Digital Converter IP-Core for FPGA at State of the Art

IEEE Access, 2021
The Field Programmable Gate Array (FPGA) structure poses several constraints that make the implementation of complex asynchronous circuits such as Time–Mode (TM) circuits almost unfeasible.
Fabio Garzetti, Nicola Corna, Nicola Lusardi, Angelo Geraci   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Time-to-Digital Converter Approach to Physical Attacks on Integrated Circuits

Electrica
Shielding is an effective way of protecting the circuitry against physical attacks. Shields are metal structures that cover the top of a circuit. Measuring the delay on these shields allows detection of physical attacks.
Hasan Kaydırma, Ali Tangel, Ahmet Unutulmaz   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source