Results 61 to 70 of about 197,559 (298)

PARISROC, a Photomultiplier Array Integrated Read Out Chip [PDF]

open access: yes, 2009
PARISROC is a complete read out chip, in AMS SiGe 0.35 !m technology, for photomultipliers array. It allows triggerless acquisition for next generation neutrino experiments and it belongs to an R&D program funded by the French national agency for ...
Berni, M. El   +6 more
core   +5 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Digital-to-Time Converter with 3.93 ps Resolution Implemented on FPGA Chips

open access: yesIEEE Access, 2017
In this paper, a digital-to-time converter (DTC) based on the principle of quantified phase shift resolution (QPSR) is proposed and tested. The QPSR principle is realized by analyzing the phase relationship between two periodic signals, which ...
Min Zhang, Hai Wang, Yan Liu
doaj   +1 more source

Digital-voltage curve generator [PDF]

open access: yes, 1970
Curve generator capable of producing precisely repeatable curve for any single-valued function of voltage versus time uses digital approach, implemented by means of clocked feedback shift register, large scale integrated circuit diode matrix comprising ...
Perlman, M.
core   +1 more source

Attractive new technologies for 7-wavelength time domain optical mammography [PDF]

open access: yes, 2017
An 8-channel Silicon PhotoMultiplier (SiPM) probe and Time-to-Digital-Converter (TDC) realize a higher-throughput, cheaper and compact detection chain for time-resolved optical mammography than photomultiplier tubes (PMTs) and Time Correlated Single ...
Cubeddu, Rinaldo   +5 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Complete and Compact 32-Channel System for Time-Correlated Single-Photon Counting Measurements

open access: yesIEEE Photonics Journal, 2013
Single-photon detectors play a key role in many research fields such as biology, chemistry, medicine, and space technology, and in recent years, single-photon avalanche diodes (SPADs) have become a valid alternative to photo multiplier tubes (PMTs ...
A. Cuccato   +6 more
doaj   +1 more source

Hybrid methods for function generation [PDF]

open access: yes, 1961
A method of function generation is discussed based on the use of hybrid digital analogue techniques. A brief description of a quantizer is given together with some experimental results.
Paul, R. J. A.
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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