Results 111 to 120 of about 891,103 (297)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Improving the Robustness of Time Difference of Arrival Estimation Based on the Energy Center of Gravity Rearrangement. [PDF]

Sensors (Basel), 2023
Zhang P, Wen H, Xu Z, Zhao Z.
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Disturbance Source Location in Power Systems Based on Time Difference of Arrival

Zhongguo dianli, 2019
The system frequency dynamics in large-scale interconnected power grids are characterized by spatial-temporal distribution, and its propagation speed is far less than the light speed.
Mengxi WEI, Ningning MA, Delin WANG, Wei DENG, Jitao KANG   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

High-Precision Time Difference of Arrival Estimation Method Based on Phase Measurement

Remote Sensing
In unmanned aerial vehicle (UAV)-based time difference of arrival (TDOA) positioning technique, baselines are limited due to communication constraints. In this case, the accuracy is highly sensitive to the TDOA measurements’ error. This article primarily
Jihao Xin, Xuyang Ge, Yuan Zhang, Xingdong Liang, Hang Li, Linghao Wu, Jiashuo Wei, Xiangxi Bu   +7 more
doaj   +1 more source

A Reliable Pipeline Leak Detection Method Using Acoustic Emission with Time Difference of Arrival and Kolmogorov-Smirnov Test. [PDF]

Sensors (Basel), 2023
Nguyen DT, Nguyen TK, Ahmad Z, Kim JM.
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Research on a Method of Locating Civil Aviation Radio Interference Sources Based on Time Difference of Arrival and Frequency Difference of Arrival for Four Unmanned Aerial Vehicles. [PDF]

Sensors (Basel), 2023
Zhou C, Zhu X, Xiong R, Hu K, Ouyang F, Huang C, Huang T.   +6 more
europepmc   +1 more source

Two‐step estimator for moving‐emitter geolocation using time difference of arrival/frequency‐difference of arrival measurements

IET Radar, Sonar & Navigation, 2015
This study presents a two‐step least‐squares approach for estimating the position and velocity of a moving emitter using time difference of arrival (TDOA) and frequency‐difference of arrival (FDOA) measurements in a two‐dimensional scenario. The proposed method first estimates the emitter position based on the asymptotes of TDOA hyperbolae and then ...
Yong‐Hee Kim, Dong‐Gyu Kim, Hyoung‐Nam Kim   +2 more
openaire   +1 more source