Results 231 to 240 of about 84,673 (295)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Dynamic Stability Analysis and Optimization of Multi-Vehicle Systems in Heterogeneous Connected Traffic. [PDF]

Sensors (Basel)
Wang T, Qu D.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Energy-efficient train timetable optimization for tram system under multi-signal priority strategies. [PDF]

Sci Rep
He J, Wang F, Duan Y, Yang Z, Yang J.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Calibration of parameters in microscopic traffic flow simulation models considering micro-meteorological information. [PDF]

PLoS One
Ma J, Zhang Y, Zhang L, Gao Z, Cao K, Fu Q, Qian Z.   +6 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Multimodality image fusion guidance in the microcatheter navigation to cerebrospinal arteriovenous fistula: Report of the two cases. [PDF]

Surg Neurol Int
Fujii G, Koizumi S, Fujitani S, Umekawa M, Ono H, Saito N.   +5 more
europepmc   +1 more source

Analysis of the distraction impact on driving performance across driving styles: A driving simulator study in various speed conditions. [PDF]

PLoS One
Faqani M, Nassiri H, Rezaei M, Ramezani M.   +3 more
europepmc   +1 more source

Dynamic road section risk identification model based on connected in-vehicle data. [PDF]

PLoS One
Zhang Y, Yang G, Xie T.
europepmc   +1 more source