Results 51 to 60 of about 197,559 (299)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Rate augmented digital to analog converter Patent [PDF]
, 1971 Development and characteristics of rate augmented digital to analog converter for computed time-dependent ...
Kopelson, S.
core +1 more source
Temperature Stable Time-to-Digital Converter [PDF]
The Journal of the Korean Institute of Information and Communication Engineering, 2012 To converter time information to digital information Time-to-Digital Converter(TDC) is designed by using analog delay elements. To obtain the temperature stable characteristics the circuit is designed and the operation of the designed circuit is confirmed by HSPICE. The characteristics variation of the designed delay element with temperature is from -0.
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
5 ps Jitter Programmable Time Interval/Frequency Generator
Metrology and Measurement Systems, 2017 A new time interval/frequency generator with a jitter below 5 ps is described. The time interval generation mechanism is based on a phase shifting method with the use of a precise DDS synthesizer. The output pulses are produced in a Spartan-6 FPGA device,
Kwiatkowski Paweł +4 more
doaj +1 more source
Special Considerations in Estate Planning for Same-Sex and Unmarried Couples [PDF]
, 2013 Sub-Nyquist sampling makes use of sparsities in analog signals to sample them at a rate lower than the Nyquist rate. The reduction in sampling rate, however, comes at the cost of additional digital signal processing (DSP) which is required to reconstruct
Johansson, Håkan +1 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Applied Sciences, 2022 This paper presents a 19 ps precision and 170 M samples/s time-to-digital converter (TDC) in FPGA. Through the direct count method and tapped delay line method, the coarse count and fine count can be extracted, respectively.
Mengdi Zhang +3 more
doaj +1 more source
Variation Resilient Adaptive Controller for Subthreshold Circuits
, 2009 Subthreshold logic is showing good promise as a viable ultra-low-power circuit design technique for power-limited applications. For this design technique to gain widespread adoption, one of the most pressing concerns is how to improve the robustness of ...
Al-Hashimi, Bashir +2 more
core +1 more source