Results 61 to 70 of about 197,559 (299)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

PARISROC, a Photomultiplier Array Integrated Read Out Chip [PDF]

, 2009
PARISROC is a complete read out chip, in AMS SiGe 0.35 !m technology, for photomultipliers array. It allows triggerless acquisition for next generation neutrino experiments and it belongs to an R&D program funded by the French national agency for ...
Berni, M. El, Campagne, J. E., De La Taille, C., Di Lorenzo, S. Conforti, Dulucq, F., Martin-Chassard, G., Wei, W.   +6 more
core   +5 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A 0.002‐mm2 8‐bit 1‐MS/s low‐power time‐based DAC (T‐DAC)

IET Circuits, Devices and Systems, 2021
Digital‐to‐analogue converters (DACs) are essential blocks for interfacing the digital environment with the real world. A novel architecture, using a digital‐to‐time converter (DTC) and a time‐to‐voltage converter (TVC), is employed to form a low‐power ...
Ali H. Hassan, Hassan Mostafa, Mohamed Refky, Khaled N. Salama, Ahmed M. Soliman   +4 more
doaj   +1 more source

Digital-voltage curve generator [PDF]

, 1970
Curve generator capable of producing precisely repeatable curve for any single-valued function of voltage versus time uses digital approach, implemented by means of clocked feedback shift register, large scale integrated circuit diode matrix comprising ...
Perlman, M.
core   +1 more source

Attractive new technologies for 7-wavelength time domain optical mammography [PDF]

, 2017
An 8-channel Silicon PhotoMultiplier (SiPM) probe and Time-to-Digital-Converter (TDC) realize a higher-throughput, cheaper and compact detection chain for time-resolved optical mammography than photomultiplier tubes (PMTs) and Time Correlated Single ...
Cubeddu, Rinaldo, Dalla Mora, Alberto, Ferocino, Edoardo, Martinenghi, Edoardo, Pifferi, Antonio, Taroni, Paola   +5 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Digital-to-Time Converter with 3.93 ps Resolution Implemented on FPGA Chips

IEEE Access, 2017
In this paper, a digital-to-time converter (DTC) based on the principle of quantified phase shift resolution (QPSR) is proposed and tested. The QPSR principle is realized by analyzing the phase relationship between two periodic signals, which ...
Min Zhang, Hai Wang, Yan Liu
doaj   +1 more source

Digital twin based monitoring and control for DC-DC converters

Nature Communications, 2023
The monitoring and control of DC-DC converters have become key issues since DC-DC converters are gradually playing increasingly crucial roles in power electronics applications such as electric vehicles and renewable energy systems.
Zhongcheng Lei, Hong Zhou, Xiaoran Dai, Wenshan Hu, Guo-Ping Liu   +4 more
doaj   +1 more source

Hybrid methods for function generation [PDF]

, 1961
A method of function generation is discussed based on the use of hybrid digital analogue techniques. A brief description of a quantizer is given together with some experimental results.
Paul, R. J. A.
core