Results 31 to 40 of about 5,625 (178)

Molecular Clocks in Translational Roadmap for Circadian‐Based Therapeutics in Lung Diseases

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
High‐amplitude circadian oscillations maintain lung immune and epithelial homeostasis. Chronic inflammation dampens peripheral clock amplitude, driving chronodisruption, barrier dysfunction, and remodeling. Clock‐targeted therapies re‐entrain the lung circadian clock, restore rhythmic immune resolution, and promote functional lung repair.
Kingshuk Panda, Renu Khasa, Srinivasan Chinnapaiyan, Saurabh Aggarwal, Irfan Rahman, Hoshang Unwalla   +5 more
wiley   +1 more source

Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD [PDF]

European Respiratory Journal, 2009
The anti-inflammatory effects of salmeterol/fluticasone (SFP), tiotropium/fluticasone (Tio+FP) and tiotropium (Tio) alone were investigated on the inflammatory cells and mediators in sputum induced from chronic obstructive pulmonary disease patients.Subjects were either newly diagnosed or had not taken any medication for 3 months prior to the study ...
D-W, Perng, C-W, Tao, K-C, Su, C-C, Tsai, L-Y, Liu, Y-C, Lee   +5 more
openaire   +2 more sources

Horizontal Heart Orientation as a Mechanistic Contributor to Platypnea–Orthodeoxia Syndrome in Patent Foramen Ovale

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Altered cardiac orientation in the presence of a patent foramen ovale (PFO) can contribute to platypnea–orthodeoxia syndrome (POS) and unexplained hypoxemia. In such cases, consideration of PFO closure may lead to significant clinical improvement.
Bijeta Keisham, Sanchit Duhan, Uday B. Kanakadandi, Osama Alsara, Naveed A. Adoni, Sanjay S. Mehta, Andrea Brasch, Haseeb Basha, Vishesh Paul   +8 more
wiley   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, Volume 81, Issue 5, Page 1617-1634, May 2026.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

A randomized multicenter Phase II study of perioperative tiotropium intervention in gastric cancer patients with chronic obstructive pulmonary disease

International Journal of COPD, 2015
Sachio Fushida,1,2 Katsunobu Oyama,1,2 Masahide Kaji,2 Yasuo Hirono,2 Jun Kinoshita,1,2 Tomoya Tsukada,1,2 Hideaki Nezuka,2 Tatsuo Nakano,2 Masahiro Noto,2 Koji Nishijima,2 Takashi Fujimura,2 Tetsuo Ohta1,2 1Department of Gastroenterological Surgery ...
Fushida S, Oyama K, Kaji M, Hirono Y, Kinoshita J, Tsukada T, Nezuka H, Nakano T, Noto M, Nishijima K, Fujimura T, Ohta T   +11 more
doaj  

Effect of 12 weeks of once-daily tiotropium/olodaterol on exercise endurance during constant work-rate cycling and endurance shuttle walking in chronic obstructive pulmonary disease

Therapeutic Advances in Respiratory Disease, 2018
Background: The TORRACTO ® study evaluated the effects of tiotropium/olodaterol versus placebo on endurance time during constant work-rate cycling and constant speed shuttle walking in patients with chronic obstructive pulmonary disease (COPD) after 12 ...
François Maltais, Denis O’Donnell, Juan Bautista Gáldiz Iturri, Anne-Marie Kirsten, Dave Singh, Alan Hamilton, Kay Tetzlaff, Yihua Zhao, Richard Casaburi   +8 more
doaj   +1 more source

Tiotropium bromide as adjunct therapy in children with asthma: a clinical experience

Allergy, Asthma & Clinical Immunology, 2021
Background The Global Initiative for Asthma has only recently added tiotropium bromide as adjunct controller therapy in severe asthma (Step 4 or 5) in adults (2015) and children (2019). Although not yet approved for pediatric use by Health Canada, it has
Zainab Ridha, Marc-Antoine Bédard, Anna Smyrnova, Olivier Drouin, Aniela Pruteanu, Sandrine Essouri, Francine M. Ducharme   +6 more
doaj   +1 more source

Oxymatrine Inhibits Epithelial‐Mesenchymal Transition to Alleviate Airway Remodeling in Chronic Obstructive Pulmonary Disease by Suppressing the TGF‐β1/Smad Pathway

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 4, April 2026.
ABSTRACT This study explored the therapeutic efficacy of oxymatrine (OMT, C15H24N2O2) in a murine model of cigarette smoke (CS)‐induced chronic obstructive pulmonary disease (COPD) and elucidated its underlying mechanisms. A COPD model was established in mice through prolonged exposure to CS, followed by intraperitoneal administration of OMT (50 mg/kg)
Shuang Zhou, Ju‐Xiang Zhu, Jing Li
wiley   +1 more source

Effects of baseline symptom burden on treatment response in COPD

International Journal of COPD, 2019
Fernando J Martinez,1 Roger A Abrahams,2,3 Gary T Ferguson,4 Leif Bjermer,5 Lars Grönke,6 Florian Voß,7 Dave Singh8 1Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, NY, USA; 2Morgantown Pulmonary ...
Martinez FJ, Abrahams RA, Ferguson GT, Bjermer L, Grönke L, Voß F, Singh D   +6 more
doaj  

Development of an enhanced health-economic model and cost-effectiveness analysis of tiotropium + olodaterol Respimat fixed-dose combination for chronic obstructive pulmonary disease patients in Italy

Therapeutic Advances in Respiratory Disease, 2016
Background: The objective of this study was to compare the cost-effectiveness of the fixed-dose combination (FDC) of tiotropium + olodaterol Respimat ® FDC with tiotropium alone for patients with chronic obstructive pulmonary disease (COPD) in the ...
Carl Selya-Hammer, Nuria Gonzalez-Rojas Guix, Michael Baldwin, Andrew Ternouth, Marc Miravitlles, Maureen Rutten-van Mölken, Lucas M.A. Goosens, Nasuh Buyukkaramikli, Valentina Acciai   +8 more
doaj   +1 more source