Results 11 to 20 of about 5,625 (178)
Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Pylkkö E +8 more
europepmc +2 more sources
International Journal of COPD, 2006 Therapy with bronchodilators forms the pharmacologic foundation of the treatment of patients with COPD. Bronchodilators can significantly lessen dyspnea, increase airflow, improve quality of life, and enhance exercise performance. While bronchodilators decrease airway resistance and lessen dynamic hyperinflation in patients with COPD, they have not ...
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Canadian Respiratory Journal, 2019 Rationale. We previously demonstrated increased expression of programmed cell death 5 (PDCD5) in asthmatic patients and ovalbumin-induced allergic asthma.
Juan Wang +3 more
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Skin reaction to inhaled tiotropium bromide: a case report
Journal of Medical Case Reports, 2011 Introduction Systemic reactions to inhaled drugs are rare. To the best of our knowledge, we report the first case of generalized itching related to the use of tiotropium bromide, a long acting inhaled anti-cholinergic agent commonly used to treat chronic
Megali Raffaella +3 more
doaj +1 more source
pharma-kritik, 2003 Tiotropium, ein neues Mittel zur Behandlung der chronisch-obstruktiven Lungenkrankheit, hat eine ähnliche Struktur wie Ipratropium, zeichnet sich aber durch eine deutlich längere Halbwertszeit aus und muss deshalb nur einmal pro Tag inhaliert werden. Tiotropium scheint mindestens so wirksam zu sein wie andere Bronchodilatatoren, ist innerhalb dieser ...
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Comparison of clinical efficacy and safety between indacaterol and tiotropium in COPD: meta-analysis of randomized controlled trials. [PDF]
PLoS ONE, 2015 Two once-daily inhaled bronchodilators, indacaterol and tiotropium, are widely used as first-line therapy in stable COPD patients. This study was performed to compare the clinical efficacy and safety between indacaterol and tiotropium in patients with ...
Jung Soo Kim +10 more
doaj +1 more source
Low Dose Theophylline and Tiotropium Rotacap as Add on Therapy in COPD Patients-Clinical Trial
Journal of Bahria University Medical and Dental College, 2021 Objectives: To compare the role of low dose Theophylline and Tiotropium rotacap in improving the lung functions and day to day life of patients suffering from COPD.
Muzna Hameed Dar +4 more
doaj +1 more source
Tiotropium Bromide: An Update [PDF]
The Open Respiratory Medicine Journal, 2009 Tiotropium bromide is a once-daily inhaled anticholinergic bronchodilator. It works by blocking the muscarinic receptors in airway smooth muscle. Tiotropium has a wide therapeutic margin, due to its poor gastrointestinal absorption and its very low systemic bioavailability. The drug is mainly indicated in COPD patients.
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Tiotropium: a new therapeutic option in asthma
Monaldi Archives for Chest Disease, 2013 Tiotropium: a new therapeutic option in asthma. F. Novelli, F. Costa, M. Latorre, L. Malagrinò, A. Celi, B. Vagaggini, P. Paggiaro. Although bronchial hyperresponsiveness to cholinergic agents is a main feature of asthma, the role of anticholinergic ...
F. Novelli +6 more
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Tiotropium in paediatric asthma [PDF]
European Respiratory Journal, 2017 No significant benefit of inhaled tiotropium was found in a trial in children and young people with severe asthmahttp://ow.ly ...
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