Results 11 to 20 of about 8,104 (211)

Improvements With Tiotropium Maintenance Therapy in COPD Patients Without Dyspnea [PDF]

MedComm, Volume 7, Issue 10, October 2026.
In a post hoc analysis of the Tie‐COPD trial, including 305 patients with mild‐to‐moderate COPD and no dyspnea (mMRC 0), 2 years of tiotropium improved lung function, lowered the annual exacerbation rate, and delayed the first clinically important deterioration, indicating benefit beyond symptom relief in a group not currently offered maintenance ...
Zihui Wang, Junfeng Lin, Guannan Cai, Fan Wu, Zhishan Deng, Qi Wan, Gaoying Tang, Cuiqiong Dai, Lifei Lu, Kunning Zhou, Xiaohui Wu, Suyin Huang, Fangyan Wu, Nanshan Zhong, Yumin Zhou, Pixin Ran   +15 more
wiley   +2 more sources

Updates in COPD Management: From Inflammatory Pathways to Targeted Therapies [PDF]

European Journal of Clinical Investigation, Volume 56, Issue 10, October 2026.
COPD is a heterogeneous disease driven by overlapping neutrophilic and eosinophilic inflammatory pathways. This review highlights the shift from symptom‐based treatment toward phenotype‐ and biomarker‐directed care. Blood eosinophils, FeNO, and IgE predict corticosteroid responsiveness and identify candidates for biologic therapy.
Sasha Raman, Sreya Rahman, Francesca Polverino, Muhammad Adrish   +3 more
wiley   +2 more sources

Improvement of Severe Volume Dependent Airway Closure With Tezepelumab: A Case Report [PDF]

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Severe asthma may be complicated by airway remodeling, manifesting as higher symptom burden, airflow limitation and reduced treatment response. The effect of biologics on lung function changes remains uncertain. We report a 31‐year‐old man with severe uncontrolled asthma and chronic rhinosinusitis with nasal polyposis, characterized by ...
Philipp Suter, Robert Greig, Rory Chan, Brian J. Lipworth   +3 more
wiley   +2 more sources

In Vivo Evaluation of Psoralen in a Copper Sulfate–Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D2, 5‐HT3A, and Muscarinic Receptors [PDF]

ChemistryOpen, Volume 15, Issue 8, August 2026.
Psoralen (PSN) demonstrates significant dose‐dependent antiemetic activity in a copper sulfate–induced chick emesis model. Integrated in vivo and in silico analyses reveal reduced retching frequency, prolonged latency, and favorable multi‐receptor interactions with D2, 5‐HT3A, and muscarinic receptors, highlighting PSN as a promising multi‐target ...
Kishor Chandra, Sharif Uddin Bahar, Khadija Akter, Mst Muslima Khatun, Samiran Sadhukhan, Progna Saha Puja, Fazley Rohan, Md Shimul Bhuia, Mohammed Alfaifi, Faisal H. Altemani, Faisal Alsenani, Salehin Sheikh, Muhammad Torequl Islam   +12 more
wiley   +2 more sources

Tiotropium and exercise training in COPD patients: Effects on dyspnea and exercise tolerance [PDF]

International Journal of COPD, 2008
Nicolino Ambrosino1, Katia Foglio2, Gianni Balzano2, Pier Luigi Paggiaro1, Patrizia Lessi3, Steven Kesten3 On behalf of the Tiotropium Multicentric Italian Study Group1Cardio-Thoracic Department, University Hospital, Pisa, Italy; 2S Maugeri Foundation ...
Nicolino Ambrosino, Katia Foglio, Gianni Balzano, Pier Luigi Paggiaro, Patrizia Lessi, Steven Kesten   +5 more
doaj   +2 more sources

A randomized multicenter Phase II study of perioperative tiotropium intervention in gastric cancer patients with chronic obstructive pulmonary disease

International Journal of COPD, 2015
Sachio Fushida,1,2 Katsunobu Oyama,1,2 Masahide Kaji,2 Yasuo Hirono,2 Jun Kinoshita,1,2 Tomoya Tsukada,1,2 Hideaki Nezuka,2 Tatsuo Nakano,2 Masahiro Noto,2 Koji Nishijima,2 Takashi Fujimura,2 Tetsuo Ohta1,2 1Department of Gastroenterological Surgery ...
Fushida S, Oyama K, Kaji M, Hirono Y, Kinoshita J, Tsukada T, Nezuka H, Nakano T, Noto M, Nishijima K, Fujimura T, Ohta T   +11 more
doaj   +1 more source

Ten years of tiotropium: clinical impact and patient perspectives

International Journal of COPD, 2013
Abebaw M Yohannes,1 Martin J Connolly,2 Nicola A Hanania31Manchester Metropolitan University, Department of Health Professions, Manchester, UK; 2University of Auckland, Freemasons’ Department of Geriatric Medicine, Auckland, New Zealand ...
Yohannes AM, Connolly MJ, Hanania NA
doaj   +1 more source

Safety of tiotropium [PDF]

BMJ, 2011
C. J. Cates, Cates, CJ
openaire   +4 more sources

Tiotropium: a new therapeutic option in asthma [PDF]

Monaldi Archives for Chest Disease, 2013
Tiotropium: a new therapeutic option in asthma. F. Novelli, F. Costa, M. Latorre, L. Malagrinò, A. Celi, B. Vagaggini, P. Paggiaro. Although bronchial hyperresponsiveness to cholinergic agents is a main feature of asthma, the role of anticholinergic ...
F. Novelli, F. Costa, M. Latorre, L. Malagrinò, A. Celi, B. Vagaggini, P. Paggiaro   +6 more
doaj   +2 more sources

Tiotropium inhibits methacholine-induced extracellular matrix production via β-catenin signaling in human airway smooth muscle cells

International Journal of COPD, 2018
Yating Huo, Lili Guan, Jiawen Xu, Luqian Zhou, Rongchang Chen State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Background: Airway ...
Huo Y, Guan L, Xu J, Zhou L, Chen R
doaj   +1 more source