Results 51 to 60 of about 7,681 (214)

Oxymatrine Inhibits Epithelial‐Mesenchymal Transition to Alleviate Airway Remodeling in Chronic Obstructive Pulmonary Disease by Suppressing the TGF‐β1/Smad Pathway

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 4, April 2026.
ABSTRACT This study explored the therapeutic efficacy of oxymatrine (OMT, C15H24N2O2) in a murine model of cigarette smoke (CS)‐induced chronic obstructive pulmonary disease (COPD) and elucidated its underlying mechanisms. A COPD model was established in mice through prolonged exposure to CS, followed by intraperitoneal administration of OMT (50 mg/kg)
Shuang Zhou, Ju‐Xiang Zhu, Jing Li
wiley   +1 more source

Rheumatoid Arthritis–Associated Pleural Effusion in an Elderly Female With Multimorbidity: A Case Report and Diagnostic Challenge

Respirology Case Reports, Volume 14, Issue 4, April 2026.
RA Pleural Effusion is a rare but clinically significant extra‐articular manifestation of RA, presenting diagnostic challenges in patients with multimorbidity. This case underscores the importance of considering autoimmune aetiologies in unexplained exudative pleural effusions, particularly when accompanied by joint symptoms or seropositivity.
Aatif Syed, Abdul Kalam Rawther, Pranav Kumar   +2 more
wiley   +1 more source

Association of Abatacept With Lower Mortality Risk Compared to Rituximab in Rheumatoid Arthritis–Associated Interstitial Lung Disease: An Emulated Target Trial

Arthritis &Rheumatology, Volume 78, Issue 3, Page 592-602, March 2026.
Objective The optimal treatment strategy for rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) remains uncertain, and direct comparative data between biologics are limited. This study aimed to evaluate the effectiveness and safety of abatacept compared with rituximab in patients with RA‐ILD.
Po‐Cheng Shih, Shiow‐Ing Wang, James Cheng Chung Wei   +2 more
wiley   +1 more source

Effect of 12 weeks of once-daily tiotropium/olodaterol on exercise endurance during constant work-rate cycling and endurance shuttle walking in chronic obstructive pulmonary disease

Therapeutic Advances in Respiratory Disease, 2018
Background: The TORRACTO ® study evaluated the effects of tiotropium/olodaterol versus placebo on endurance time during constant work-rate cycling and constant speed shuttle walking in patients with chronic obstructive pulmonary disease (COPD) after 12 ...
François Maltais, Denis O’Donnell, Juan Bautista Gáldiz Iturri, Anne-Marie Kirsten, Dave Singh, Alan Hamilton, Kay Tetzlaff, Yihua Zhao, Richard Casaburi   +8 more
doaj   +1 more source

Tiotropium/Olodaterol treatment reduces cigarette smoke extract-induced cell death in BEAS-2B bronchial epithelial cells

BMC Pharmacology and Toxicology, 2020
Background Cigarette smoking is a critical risk factor for the destruction of lung parenchyma or the development of emphysema, which is characteristic of COPD.
Cheng-hsiung Chen, Yi-Rong Li, Sheng-Hao Lin, Hsiu-Hui Chang, Woei-Horng Chai, Po-Chiang Chan, Ching-Hsiung Lin   +6 more
doaj   +1 more source

New approaches to treating chronic obstructive pulmonary disease with Colla corii asini

Animal Models and Experimental Medicine, Volume 9, Issue 1, Page 50-58, January 2026.
Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang, Siman Sun, Xiaoyu Fan, Jiuming He, Qing Li, Hongtao Jin   +5 more
wiley   +1 more source

Comparative Characterization of Lung Muscarinic Receptor Binding After Intratracheal Administration of Tiotropium, Ipratropium, and Glycopyrrolate

Journal of Pharmacological Sciences, 2011
The aim of the current study was to characterize comparatively the binding of muscarinic receptor in the lung of rats intratracheally administered anticholinergic agents (tiotropium, ipratropium, glycopyrrolate) used clinically to treat chronic ...
Masaki Ogoda, Ryo Niiya, Tadatsura Koshika, Shizuo Yamada   +3 more
doaj   +1 more source

Tiotropium bromide as adjunct therapy in children with asthma: a clinical experience

Allergy, Asthma & Clinical Immunology, 2021
Background The Global Initiative for Asthma has only recently added tiotropium bromide as adjunct controller therapy in severe asthma (Step 4 or 5) in adults (2015) and children (2019). Although not yet approved for pediatric use by Health Canada, it has
Zainab Ridha, Marc-Antoine Bédard, Anna Smyrnova, Olivier Drouin, Aniela Pruteanu, Sandrine Essouri, Francine M. Ducharme   +6 more
doaj   +1 more source

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel, Alejandro Flores, Maedeh Darsaraee, Jean‐Louis Reymond   +3 more
wiley   +1 more source

Effects of baseline symptom burden on treatment response in COPD

International Journal of COPD, 2019
Fernando J Martinez,1 Roger A Abrahams,2,3 Gary T Ferguson,4 Leif Bjermer,5 Lars Grönke,6 Florian Voß,7 Dave Singh8 1Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, NY, USA; 2Morgantown Pulmonary ...
Martinez FJ, Abrahams RA, Ferguson GT, Bjermer L, Grönke L, Voß F, Singh D   +6 more
doaj