Results 41 to 50 of about 7,936 (162)

Efficacy of Dupilumab in a Woman With Severe Asthma Complicated by Eosinophilic Sinusitis and a Desire to Have a Baby: A Case Report

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Since 2008, the patient had been undergoing asthma treatment, but it was poorly controlled. She also had comorbid conditions including eosinophilic sinusitis, allergic rhinitis, conjunctivitis, and a non‐functional adrenal tumor. After marriage in 2018 (age 34 years), her asthma control remained poor, and she was unable to conceive spontaneously ...
Akari Neoi, Masakiyo Yatomi, Yurino Nagata, Daisuke Higeta, Daisuke Shimizu, Karin Kuno, Yuri Sawada, Mari Sato, Haruka Aoki‐Saito, Koichi Yamaguchi, Hiroaki Tsurumaki, Yosuke Miura, Kenichiro Hara, Noriaki Sunaga, Yasuhiko Koga, Kazuaki Chikamatsu, Takeshi Hisada, Toshitaka Maeno   +17 more
wiley   +1 more source

Development of an enhanced health-economic model and cost-effectiveness analysis of tiotropium + olodaterol Respimat fixed-dose combination for chronic obstructive pulmonary disease patients in Italy

Therapeutic Advances in Respiratory Disease, 2016
Background: The objective of this study was to compare the cost-effectiveness of the fixed-dose combination (FDC) of tiotropium + olodaterol Respimat ® FDC with tiotropium alone for patients with chronic obstructive pulmonary disease (COPD) in the ...
Carl Selya-Hammer, Nuria Gonzalez-Rojas Guix, Michael Baldwin, Andrew Ternouth, Marc Miravitlles, Maureen Rutten-van Mölken, Lucas M.A. Goosens, Nasuh Buyukkaramikli, Valentina Acciai   +8 more
doaj   +1 more source

Linezolid‐Associated Lactic Acidosis Triggering a Sepsis Alert: A Case Report

Clinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT Elevated lactate alone may trigger false sepsis alerts. In this case, linezolid‐induced lactic acidosis mimicked sepsis, triggering automated alerts. Clinicians should consider medication‐related causes of lactate elevation and apply clinical context in interpreting automated alerts to avoid unnecessary interventions, alert fatigue, and ...
Yusuf Kagzi, Moni Roy, Tulika Chatterjee
wiley   +1 more source

Comparative efficacy of aclidinium versus glycopyrronium and tiotropium, as maintenance treatment of moderate to severe COPD patients: a systematic review and network meta-analysis

International Journal of COPD, 2013
Andreas Karabis,1 Leandro Lindner,2 Michelle Mocarski,3 Eline Huisman,1 Andrew Greening4 1MAPI Consultancy, AX Houten, The Netherlands; 2Almirall SA, Barcelona, Spain; 3Health Economics and Outcomes Research, Forest Research Institute, Jersey City, NJ ...
Karabis A, Lindner L, Mocarski M, Huisman E, Greening A   +4 more
doaj  

Efficacy of inhaled tiotropium add-on to budesonide/formoterol in patients with bronchiolitis obliterans developing after hematopoietic stem cell transplantation [PDF]

, 2022
Jeong Uk Lim, Silvia Park, Jae‐Ho Yoon, Sung‐Eun Lee, Byung‐Sik Cho, Yoo‐Jin Kim, Seok Lee, Hee‐Je Kim, Chin Kook Rhee   +8 more
openalex   +1 more source

Impact of Mechanistic Modeling and Simulation Methodologies on Product‐Specific Guidance Development for Non‐Orally Administered Drug Products

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 9, Page 1421-1430, September 2025.
ABSTRACT The U.S. Food and Drug Administration (FDA) publishes product‐specific guidances (PSGs), with bioequivalence (BE) recommendations for prospective generics. Developing BE recommendations for non‐orally administered drug products including long‐acting injectables (LAI), orally inhaled drug products, and drugs applied locally to the skin ...
Steven G. Chopski, Ross L. Walenga, Ming‐Liang Tan, Khondoker Alam, Andrew Babiskin, Lanyan Fang, Eleftheria Tsakalozou   +6 more
wiley   +1 more source

Efficacy of tiotropium/olodaterol on lung volume, exercise capacity, and physical activity

International Journal of COPD, 2018
Masakazu Ichinose,1 Yoshiaki Minakata,2 Takashi Motegi,3 Jun Ueki,4 Yasuhiro Gon,5 Tetsuo Seki,6 Tatsuhiko Anzai,7 Shuhei Nakamura,6 Kazuto Hirata8 1Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 2Department of
Ichinose M, Minakata Y, Motegi T, Ueki J, Gon Y, Seki T, Anzai T, Nakamura S, Hirata K   +8 more
doaj  

Effect of Tiotropium Soft Mist Inhalers on Dynamic Changes in Lung Mechanics of Patients with Chronic Obstructive Pulmonary Disease Receiving Mechanical Ventilation: A Prospective Pilot Study

Pharmaceutics, 2020
The effects of tiotropium bromide soft mist inhalers (SMIs) in patients with chronic obstructive pulmonary disease (COPD) receiving mechanical ventilation remain unexplored.
Pin-Kuei Fu, Yu-Feng Wei, Chau-Chyun Sheu, Chen-Yu Wang, Chi-Kuei Hsu, Chia-Min Chen, Wei-Chih Chen, Kuang-Yao Yang   +7 more
doaj   +1 more source

SINGLE-INHALER TRIPLE THERAPY FLUTICASONE FUROATE/UMECLIDINIUM/VILANTEROL COMPARED WITH TIOTROPIUM MONOTHERAPY IN COPD: A POST HOC ANALYSIS BY AIRFLOW LIMITATION [PDF]

, 2020
Antonio Anzueto, Dany Obeid, Sandeep Bansal, Nicola J. Brown, Christopher Compton, Thomas Corbridge, Kelly Dorais, David Erb, Catherine Harvey, Morrys C. Kaisermann, Mitchell Kaye, David A. Lipson, Neil A. Martin, Chang‐Qing Zhu, Alberto Papi   +14 more
openalex   +1 more source

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, Volume 182, Issue 17, Page 4122-4133, September 2025.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source