Results 101 to 110 of about 5,292 (260)

Ten years of tiotropium: clinical impact and patient perspectives

International Journal of COPD, 2013
Abebaw M Yohannes,1 Martin J Connolly,2 Nicola A Hanania31Manchester Metropolitan University, Department of Health Professions, Manchester, UK; 2University of Auckland, Freemasons’ Department of Geriatric Medicine, Auckland, New Zealand ...
Yohannes AM, Connolly MJ, Hanania NA
doaj  

Detection of doping peptides and basic drugs in equine urine using liquid chromatography–mass spectrometry

Drug Testing and Analysis, Volume 16, Issue 4, Page 406-419, April 2024.
Equine urine was processed using solid phase extraction on a weak cation exchange sorbent followed by detection using positive mode electrospray ionization on a triple quadrupole mass spectrometer. The method was able to detect over 50 different substances including peptides and quaternary ammonium drugs.
Luis Flores, Sabine Hargrave, Amel Clifford, Gwendolyne Alarcio, Benjamin C. Moeller   +4 more
wiley   +1 more source

Comparative efficacy of long-acting bronchodilators for COPD - a network meta-analysis [PDF]

, 2013
Background: Clinicians are faced with an increasingly difficult choice regarding the optimal bronchodilator for patients with chronic obstructive pulmonary disease (COPD) given the number of new treatments. The objective of this study is to evaluate the
Baldwin, M, Buckley, F, Capkun-Niggli, G, Cope, S, Donohue, JF, Ellis, A, Jansen, JP, Jones, P, Kraemer, M   +8 more
core   +3 more sources

Transition on the entropic elasticity of DNA induced by intercalating molecules [PDF]

, 2007
We use optical tweezers to perform stretching experiments on DNA molecules when interacting with the drugs daunomycin and ethidium bromide, which intercalate the DNA molecule. These experiments are performed in the low-force regime from zero up to 2 pN.
arxiv   +1 more source

Efficacy of tezepelumab against uncontrolled severe non‐type 2 asthma refractory to bronchial thermoplasty, benralizumab, dupilumab and mepolizumab

Respirology Case Reports, Volume 12, Issue 3, March 2024.
Severe asthma is defined as asthma uncontrolled despite treatment with high‐dose inhaled corticosteroids (ICS) and long‐acting β2‐agonists. Herein, we describe a case of non‐type 2 asthma that progressively worsened over the years. We review the case history and detail the case management. Abstract Severe asthma affects approximately 5%–10% of patients
Yoshiro Kai, Kentaro Suzuki, Ryosuke Kataoka, Ichiro Sato, Shinji Tamaki, Shigeo Muro   +5 more
wiley   +1 more source

Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD [PDF]

, 2015
Objective We performed a review of studies of fluticasone propionate (FP)/salmeterol (SAL) (combination inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA)) in patients with COPD, which measured baseline (pretreatment) blood eosinophil levels, to ...
Barnes, NC, Jones, PW, Lettis, S, Locantore, N, Pascoe, S, Pavord, ID, Wedzicha, JA   +6 more
core   +1 more source

A perspective current and past modes of inhalation therapy

Microbial Biotechnology, Volume 17, Issue 2, February 2024.
Abstract Inhalation is the preferred route of delivery for anti‐asthma and chronic obstructive pulmonary disease (COPD) drugs. The use of this route has demonstrated efficacy in these and other conditions, it offers rapid onset of action, and is associated with minimal systemic exposure, thereby reducing the risk of adverse effects.
José Canto Mangana, Kelsey Aguirre Schilder, José Ignacio Bretones‐Pedrinaci, Ana Rosa Márquez Blesa, Fermín Sánchez de Medina, Olga Martínez‐Augustin, Abdelali Daddaoua   +6 more
wiley   +1 more source

Colloidal quasi-2D Methylammonium Lead Bromide Perovskite Nanostructures with Tunable Shape and High Chemical Stability [PDF]

Small 20 (2024) 2405758
Control over the lateral dimensions of colloidal nanostructures is a complex task which requires a deep understanding of the formation mechanism and reactivity in the corresponding systems. As a result, it provides a well-founded insight to the physical and chemical properties of these materials.
arxiv   +1 more source

Trends in medication use at the onset of and during the COVID‐19 pandemic in the Republic of Ireland: An interrupted time series study

Basic &Clinical Pharmacology &Toxicology, Volume 134, Issue 2, Page 231-240, February 2024.
Abstract The COVID‐19 pandemic had a substantial impact on healthcare delivery, particularly in general practice. This study aimed to evaluate how dispensing of medications in primary care in Ireland changed following the COVID‐19 pandemic's onset compared to expected trends.
Molly Mattsson, Jung Ah Hong, John Scott Frazer, Glenn Ross Frazer, Frank Moriarty   +4 more
wiley   +1 more source

Lack of protective effect of tiotropium vs induced dynamic hyperinflation in moderate COPD [PDF]

, 2011
SummaryStudy objectiveNovel evaluation of protective effect of tiotropium against induced dynamic hyperinflation (DH) during metronome paced hyperventilation (MPH) in moderate COPD.MethodsProspective, randomized, double-blind, placebo control, crossover ...
Fraser, Christine, Gelb, Arthur F., Zamel, Noe   +2 more
core   +1 more source