Update on Long-Acting Anticholinergics in Children and Adolescents With Difficult and Severe Asthma [PDF]
Frontiers in Pediatrics, 2022 Tiotropium bromide is the only long-acting muscarinic antagonist (LAMA) approved for treatment of patients aged ≥6 years old who have symptoms of uncontrolled asthma.
Francesca Santamaria +4 more
doaj +6 more sources
Preparation and Evaluation of Mucus-Penetrating Inhalable Microparticles of Tiotropium Bromide Containing Sodium Glycocholate [PDF]
Pharmaceutics, 2022 This study aimed to prepare mucus-penetrating inhalable microparticles for dry powder inhalers and to evaluate their applicability in an asthma-induced rat model. Microparticles were prepared from water solutions containing tiotropium bromide, L-leucine,
Yong-Bin Kwon +5 more
doaj +2 more sources
The evidence on tiotropium bromide in asthma: from the rationale to the bedside. [PDF]
Multidiscip Respir Med, 2017 Severe and poorly controlled asthma still accounts for a great portion of the patients affected. Disease control and future risk management have been identified by international guidelines as the main goals in patients with asthma. The need for new treatment approaches has led to reconsider anticholinergic drugs as an option for asthma treatment ...
Radovanovic D +3 more
europepmc +7 more sources
Effect of Tiotropium Bromide on Airway Inflammation and Programmed Cell Death 5 in a Mouse Model of Ovalbumin-Induced Allergic Asthma [PDF]
Canadian Respiratory Journal, 2019 Rationale. We previously demonstrated increased expression of programmed cell death 5 (PDCD5) in asthmatic patients and ovalbumin-induced allergic asthma.
Juan Wang +3 more
doaj +2 more sources
International Journal of COPD, 2006 Therapy with bronchodilators forms the pharmacologic foundation of the treatment of patients with COPD. Bronchodilators can significantly lessen dyspnea, increase airflow, improve quality of life, and enhance exercise performance. While bronchodilators decrease airway resistance and lessen dynamic hyperinflation in patients with COPD, they have not ...
David A. Lipson
+5 more sources
Impact of Long-Term Tiotropium Bromide Therapy on Annual Lung Function Decline in Adult Patients with Cystic Fibrosis. [PDF]
PLoS ONE, 2016 Chronic lung disease is the leading cause of death in patients with Cystic Fibrosis (CF) and is often treated with bronchodilators. It is not known whether long-term tiotropium bromide treatment may have a positive impact on lung function.This ...
Claudia Brandt +5 more
doaj +2 more sources
Management of Chronic Obstructive Pulmonary Disease with Tiotropium Bromide [PDF]
Clinical Medicine Insights: Therapeutics, 2010 In COPD, pathologic upregulation and stimulation of muscarinic (M) receptors contribute to bronchospasm, mucus hypersecretion and possibly airway remodeling. Tiotropium bromide (brand name Spiriva; Boehringer Ingelheim/Pfizer) inhalational powder was approved by the US Food and Drug Administration in January 2004 for the long-term, once-daily ...
A.J. Mamary, Gerard J. Criner
openalex +3 more sources
Efficacy and Safety of Aclidinium Bromide Compared with Placebo and Tiotropium in Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease: Results from a 6-week, Randomized, Controlled Phase Iiib Study [PDF]
COPD, 2013 Background: This randomized, double-blind, Phase IIIb study evaluated the 24-hour bronchodilatory efficacy of aclidinium bromide versus placebo and tiotropium in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD).
Jutta Beier +6 more
doaj +2 more sources
Acta Biomedica Scientifica, 2018 The aim of the study was to investigate the effectiveness of tiotropium bromide in patients with severe persistent asthma under conditions of real clinical practice.
A. F. Ivanov, B. A. Chernyak
doaj +3 more sources
Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease
Cochrane Database of Systematic Reviews, 2015 Tiotropium and ipratropium bromide are both recognised treatments in the management of people with stable chronic obstructive pulmonary disease (COPD). There are new studies which have compared tiotropium with ipratropium bromide, making an update necessary.To compare the relative effects of tiotropium to ipratropium bromide on markers of quality of ...
Leanne Cheyne +2 more
openalex +6 more sources