Results 41 to 50 of about 2,552 (169)

Isolated Unilateral Pleural Effusion Associated With Hypothyroidism: A Case Report and Review of the Literature

Respirology Case Reports, Volume 13, Issue 11, November 2025.
Hypothyroidism rarely causes isolated pleural effusion, as such effusions are typically associated with comorbidities like heart failure or malignancy. This report presents a case of borderline transudative pleural effusion attributed solely to hypothyroidism after thorough differential diagnosis. Hypothyroidism should be considered in the differential
Hesam Amini, Fereshteh Attaran, Sara Soltanmohammadi   +2 more
wiley   +1 more source

Suppression of IL-8 production from airway cells by tiotropium bromide in vitro

International Journal of COPD, 2011
Isao Suzaki1, Kazuhito Asano2, Yusuke Shikama3, Taisuke Hamasaki1, Ayako Kanei1, Harumi Suzaki11Department of Otorhinolaryngology, School of Medicine, Showa University, Tokyo, Japan; 2Division of Physiology, School of Nursing and Rehabilitation Sciences,
Suzaki I, Asano K, Shikama Y, Hamasaki T, Kanei A, Suzaki H   +5 more
doaj  

Efficacy of Dupilumab in a Woman With Severe Asthma Complicated by Eosinophilic Sinusitis and a Desire to Have a Baby: A Case Report

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Since 2008, the patient had been undergoing asthma treatment, but it was poorly controlled. She also had comorbid conditions including eosinophilic sinusitis, allergic rhinitis, conjunctivitis, and a non‐functional adrenal tumor. After marriage in 2018 (age 34 years), her asthma control remained poor, and she was unable to conceive spontaneously ...
Akari Neoi, Masakiyo Yatomi, Yurino Nagata, Daisuke Higeta, Daisuke Shimizu, Karin Kuno, Yuri Sawada, Mari Sato, Haruka Aoki‐Saito, Koichi Yamaguchi, Hiroaki Tsurumaki, Yosuke Miura, Kenichiro Hara, Noriaki Sunaga, Yasuhiko Koga, Kazuaki Chikamatsu, Takeshi Hisada, Toshitaka Maeno   +17 more
wiley   +1 more source

Clinical effectiveness of anticholinergic tiotropium bromide as an add-on therapy in patients with severe bronchial asthma: A randomized controlled trial

Indian Journal of Health Sciences and Biomedical Research KLEU, 2017
Background and Objectives: Severe asthma seen in substantial proportion of patients has been a poorly controlled disease, with recurring symptoms and exacerbations despite the use of inhaled glucocorticoids (ICS), long-acting beta-agonists (LABAs-2 ...
V G Santhosh, Gajanan S Gaude, Jyothi Hattiholi   +2 more
doaj   +1 more source

Impact of Mechanistic Modeling and Simulation Methodologies on Product‐Specific Guidance Development for Non‐Orally Administered Drug Products

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 9, Page 1421-1430, September 2025.
ABSTRACT The U.S. Food and Drug Administration (FDA) publishes product‐specific guidances (PSGs), with bioequivalence (BE) recommendations for prospective generics. Developing BE recommendations for non‐orally administered drug products including long‐acting injectables (LAI), orally inhaled drug products, and drugs applied locally to the skin ...
Steven G. Chopski, Ross L. Walenga, Ming‐Liang Tan, Khondoker Alam, Andrew Babiskin, Lanyan Fang, Eleftheria Tsakalozou   +6 more
wiley   +1 more source

Dynamics of somatogenic comorbid anxiety-depressive disorders expression under the tiotropium bromide treatment influence

Бюллетень сибирской медицины, 2011
The aim of comparative research was the estimation of alarm and depression dynamics at patients with stable chronic obstructive pulmonary disease under influence of tiotropium treatment on HADS questionnaire.
S. V. Fedosenko, N. A. Kirillova
doaj   +1 more source

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, Volume 182, Issue 17, Page 4122-4133, September 2025.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

Breathing and balance: Clinical insights and management strategies of respiratory acid‐base disorders

Nutrition in Clinical Practice, Volume 40, Issue 4, Page 774-792, August 2025.
Abstract Respiratory acidosis and alkalosis are two of the four main acid‐base processes encountered in clinical practice. These two processes are tightly balanced by breathing. Identification and management of respiratory acid‐base disorders are important for clinicians, particularly when caring for patients with underlying pulmonary and neurological ...
Anne M. Tucker, Tami N. Johnson
wiley   +1 more source

Ten years of tiotropium: clinical impact and patient perspectives

International Journal of COPD, 2013
Abebaw M Yohannes,1 Martin J Connolly,2 Nicola A Hanania31Manchester Metropolitan University, Department of Health Professions, Manchester, UK; 2University of Auckland, Freemasons’ Department of Geriatric Medicine, Auckland, New Zealand ...
Yohannes AM, Connolly MJ, Hanania NA
doaj  

Multiomic Integration Analysis for Monitoring Severe Asthma Treated With Mepolizumab or Omalizumab

Allergy, Volume 80, Issue 7, Page 1899-1911, July 2025.
Mepolizumab and omalizumab induce a distinct clinical effect. Mepolizumab and omalizumab induce both common and treatment‐specific metabolic and protein profiles over time in patients with severe asthma. Multiomic integration and receiver operating characteristic curve analyses reveal a specific set of biomolecules suggesting their value as potential ...
Nuria Contreras, Andrea Escolar‐Peña, María I. Delgado‐Dolset, Paloma Fernández, David Obeso, Elena Izquierdo, Heleia González Cuervo, José Ángel Cumplido, Victoria Múgica, Carolina Cisneros, Santiago Angulo‐Díaz‐Parreño, Coral Barbas, Carlos Blanco, Teresa Carrillo, Domingo Barber, Alma Villaseñor, María M. Escribese   +16 more
wiley   +1 more source