Results 61 to 70 of about 3,023 (195)

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, Volume 182, Issue 17, Page 4122-4133, September 2025.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

Dynamics of somatogenic comorbid anxiety-depressive disorders expression under the tiotropium bromide treatment influence

Бюллетень сибирской медицины, 2011
The aim of comparative research was the estimation of alarm and depression dynamics at patients with stable chronic obstructive pulmonary disease under influence of tiotropium treatment on HADS questionnaire.
S. V. Fedosenko, N. A. Kirillova
doaj   +1 more source

Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease

, 1995
Tiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease (COPD). Binding studies with [3H]tiotropium bromide in human lung have confirmed that
Belvisi, MG, Judith C.W. Mak, Barnes, PJ, El-Bdaoui Haddad, Peter J Barnes, O'connor, B, Mak, JCW, Haddad, EB, Maria G Belvisi, Brian O'Connor   +9 more
core   +1 more source

Co-administration of indacaterol and tiotropium bromide for the treatment of chronic obstructive pulmonary disease and bronchiectasis, and effect on IL-8 and CRP levels

, 2023
Purpose: To investigate the efficacy of indacaterol plus tiotropium bromide in chronic obstructive pulmonary disease (COPD) complicated by bronchiectasis and the impact on IL-8 and C reactive protein (CRP) levels.Methods: Sixty enrolled patients with ...
Han, Huating, Wang, Xuerong, Wu, Xiaodong   +2 more
core   +1 more source

Breathing and balance: Clinical insights and management strategies of respiratory acid‐base disorders

Nutrition in Clinical Practice, Volume 40, Issue 4, Page 774-792, August 2025.
Abstract Respiratory acidosis and alkalosis are two of the four main acid‐base processes encountered in clinical practice. These two processes are tightly balanced by breathing. Identification and management of respiratory acid‐base disorders are important for clinicians, particularly when caring for patients with underlying pulmonary and neurological ...
Anne M. Tucker, Tami N. Johnson
wiley   +1 more source

Effect of tiotropium bromide on the cardiovascular response to exercise in COPD [PDF]

Respiratory Medicine, 2007
Exercise limitation and exertional dyspnea are important symptoms of chronic obstructive pulmonary disease (COPD), which may be partially relieved by tiotropium. Although the mechanism of relief is multifactorial, improved dynamic ventilatory mechanics appear to be important.
Travers, J., Laveneziana, P., Webb, K.A., Kesten, S., O’Donnell, D.E.   +4 more
openaire   +2 more sources

Multiomic Integration Analysis for Monitoring Severe Asthma Treated With Mepolizumab or Omalizumab

Allergy, Volume 80, Issue 7, Page 1899-1911, July 2025.
Mepolizumab and omalizumab induce a distinct clinical effect. Mepolizumab and omalizumab induce both common and treatment‐specific metabolic and protein profiles over time in patients with severe asthma. Multiomic integration and receiver operating characteristic curve analyses reveal a specific set of biomolecules suggesting their value as potential ...
Nuria Contreras, Andrea Escolar‐Peña, María I. Delgado‐Dolset, Paloma Fernández, David Obeso, Elena Izquierdo, Heleia González Cuervo, José Ángel Cumplido, Victoria Múgica, Carolina Cisneros, Santiago Angulo‐Díaz‐Parreño, Coral Barbas, Carlos Blanco, Teresa Carrillo, Domingo Barber, Alma Villaseñor, María M. Escribese   +16 more
wiley   +1 more source

Health status in the TORCH study of COPD: treatment efficacy and other determinants of change. [PDF]

, 2011
BACKGROUND: Little is known about factors that determine health status decline in clinical trials of COPD. OBJECTIVES: To examine health status changes over 3 years in the TORCH study of salmeterol+fluticasone propionate (SFC) vs.
Jones, PW, Anderson, Julie A., Vestbo Jørgen, Julie A Anderson, Yates, JC, Calverley Peter MA, Bartolome R Celli, Jenkins Christine, Gary T Ferguson, Celli, Bartolome, Vestbo, Jorgen; id_orcid, Jenkins, C ; https://orcid.org/, Calverley, Peter M A, Ferguson, Gary T, Vestbo, J, Celli, Bartolome R., null null, Vestbo, Jørgen, Paul W Jones, Jones, Paul W., Julie C Yates, Jørgen Vestbo, Yates, Julie C., Christine Jenkins, Jones, Paul W, Yates, Julie C, Yates Julie C, Vestbo, Jorgen, TORCH investigators, Celli Bartolome R, Calverley, PMA, Calverley, PM, Anderson Julie A, Anderson, JA, Jones Paul W, Ferguson Gary T, Jenkins, Christine, Ferguson, GT, Jenkins, C, Anderson, Julie A, Spencer, Michael D., Celli, BR, Calverley, Peter MA, Peter MA Calverley, Ferguson, Gary T., Michael D Spencer, Spencer, MD, Spencer Michael D, Spencer, Michael D, Celli, Bartolome R   +49 more
core   +1 more source

Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats

British Journal of Pharmacology, Volume 182, Issue 11, Page 2487-2502, June 2025.
Background and Purpose Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non‐gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the GI tract to be questioned.
Sara Traserra, Terence Appelqvist, Robert Lange, Maura Corsetti, Marcel Jimenez   +4 more
wiley   +1 more source

Management of Chronic Obstructive Pulmonary Disease with Tiotropium Bromide

, 2010
In COPD, pathologic upregulation and stimulation of muscarinic (M) receptors contribute to bronchospasm, mucus hypersecretion and possibly airway remodeling.
A. James Mamary, Gerard J. Criner
core   +1 more source