Results 51 to 60 of about 3,023 (195)
Spirocyclic Diamine Scaffolds for Medicinal Chemistry
Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel +3 more
wiley +1 more source
Tiotropium in chronic obstructive pulmonary disease – a review of clinical development
Respiratory Research, 2020 Background Bronchodilators are the mainstay of pharmacological treatment in chronic obstructive pulmonary disease (COPD), and long-acting muscarinic antagonist (LAMA) monotherapy is recommended as initial treatment for Global Initiative for Chronic ...
Antonio Anzueto, Marc Miravitlles
doaj +1 more source
, 2011 BACKGROUND: Interactions between spirometry and patient-reported outcomes in COPD are not well understood. This systematic review and study-level analysis investigated the relationship between changes in FEV1 and changes in health status with ...
PW, Jones +18 more
core +1 more source
British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3489-3500, December 2025.Aim Drugs with anticholinergic effects are often considered as potentially inappropriate medications, especially for older patients, and deprescribing such drugs may improve cognitive function. The aim was to investigate the effectiveness of counselling on drug risks as part of a multimodal intervention to prevent cognitive decline. Methods The AgeWell.
Laura K. Lepenies +14 more
wiley +1 more source
Pediatric Pulmonology, Volume 60, Issue 12, December 2025.ABSTRACT Background In cystic fibrosis (CF), the defect of the CF transmembrane conductance regulator (CFTR) can also affect sensory nerve cell function, as recently demonstrated in animal models. The aim of this prospective cohort study was to investigate whether taste and smell disorders in CF correlate with persistent CFTR dysfunction detectable by ...
Lea Christiane Beermann +9 more
wiley +1 more source
Changing patterns in long-acting bronchodilator trials in chronic obstructive pulmonary disease.
, 2011 Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Developments in the understanding of COPD have led to standard guidelines for diagnosis, treatment, and spirometry assessments, which have in turn ...
James Donohue +5 more
core +1 more source
Respirology Case Reports, Volume 13, Issue 11, November 2025.Hypothyroidism rarely causes isolated pleural effusion, as such effusions are typically associated with comorbidities like heart failure or malignancy. This report presents a case of borderline transudative pleural effusion attributed solely to hypothyroidism after thorough differential diagnosis. Hypothyroidism should be considered in the differential
Hesam Amini +2 more
wiley +1 more source
Clinical Case Reports, Volume 13, Issue 10, October 2025.Since 2008, the patient had been undergoing asthma treatment, but it was poorly controlled. She also had comorbid conditions including eosinophilic sinusitis, allergic rhinitis, conjunctivitis, and a non‐functional adrenal tumor. After marriage in 2018 (age 34 years), her asthma control remained poor, and she was unable to conceive spontaneously ...
Akari Neoi +17 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 9, Page 1421-1430, September 2025.ABSTRACT The U.S. Food and Drug Administration (FDA) publishes product‐specific guidances (PSGs), with bioequivalence (BE) recommendations for prospective generics. Developing BE recommendations for non‐orally administered drug products including long‐acting injectables (LAI), orally inhaled drug products, and drugs applied locally to the skin ...
Steven G. Chopski +6 more
wiley +1 more source
Indian Journal of Health Sciences and Biomedical Research KLEU, 2017 Background and Objectives: Severe asthma seen in substantial proportion of patients has been a poorly controlled disease, with recurring symptoms and exacerbations despite the use of inhaled glucocorticoids (ICS), long-acting beta-agonists (LABAs-2 ...
V G Santhosh +2 more
doaj +1 more source