Results 51 to 60 of about 210,372 (257)

Real-Time, Continuous Monitoring of Tissue Chips as an Emerging Opportunity for Biosensing

Sensors
Tissue chips (TCs), otherwise known as organs-on-a-chip (OoC), organ chips (OCs), or microphysiological systems (MPS), are rapidly gaining prominence as an extension of or even replacement for traditional animal models of disease physiology.
John S. Cognetti, Benjamin L. Miller
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bone Marrow Microenvironment-On-Chip for Culture of Functional Hematopoietic Stem Cells

Frontiers in Bioengineering and Biotechnology, 2022
Hematopoiesis takes place in the bone marrow and is supported by a complex cellular and molecular network in the bone marrow microenvironment. Commonly used models of the human bone marrow microenvironment include murine models and two-dimensional and ...
Azmeer Sharipol, Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Celia A. Soto, Benjamin J. Frisch, Benjamin J. Frisch, Benjamin J. Frisch, Benjamin J. Frisch   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An integrated mechanical and electrophysiological platform: towards multifunctional tissue-on-a-chip

, 2023
Cell culture in vitro platform is an indispensable tool for biology and is widely used in academic research and industrial practice in various fields ranging from fundamental biomolecule study to tissue engineering and regenerative medicine. Numerous engineering approaches are incorporated to optimize the culture condition and extend its capability ...
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Etiologies of endometriosis and model systems: is there a risk of a tunnel vision?

Frontiers in Medicine
Endometriosis is the growth of endometrial-like tissue at non-uterine locations, primarily within the peritoneal cavity. The disease can have diverse presentations with superficial lesions, deep invading lesions and ovarian cysts (endometrioma) as the ...
Mary Ann Manavalan, Mona Babtain, Myrthe Weessies, Annemiek Nap, Wouter P. R. Verdurmen, Sebastien Taurin, Mai Sater, Roland Brock, Roland Brock   +8 more
doaj   +1 more source

Microfluidic-Based 3D Engineered Microvascular Networks and Their Applications in Vascularized Microtumor Models

Micromachines, 2018
The microvasculature plays a critical role in human physiology and is closely associated to various human diseases. By combining advanced microfluidic-based techniques, the engineered 3D microvascular network model provides a precise and reproducible ...
Xiaolin Wang, Qiyue Sun, Jianghua Pei
doaj   +1 more source

Research Resource: Whole-Genome Estrogen Receptor α Binding in Mouse Uterine Tissue Revealed by ChIP-Seq [PDF]

Molecular Endocrinology, 2012
Abstract To advance understanding of mechanisms leading to biological and transcriptional endpoints related to estrogen action in the mouse uterus, we have mapped ERα and RNA polymerase II (PolII) binding sites using chromatin immunoprecipitation followed by sequencing of enriched chromatin fragments.
Sylvia C, Hewitt, Leping, Li, Sara A, Grimm, Yu, Chen, Liwen, Liu, Yin, Li, Pierre R, Bushel, David, Fargo, Kenneth S, Korach   +8 more
openaire   +2 more sources