Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth [PDF]
, 2013 Due to strong light scattering in tissue, both the spatial resolution and maximum penetration depth of optical-resolution photoacoustic microscopy (OR-PAM) deteriorate sharply with depth.
Wang, Lihong V., Yao, Junjie, Zhou, Yong
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Tissue clearing and its applications in neuroscience [PDF]
Nature Reviews Neuroscience, 2020 State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact tissues from individual organs and even to some entire mammals. When combined with light-sheet microscopy and automated approaches to image analysis, existing tissue-clearing methods can speed up and may reduce the cost of conventional histology by several ...
Hiroki R. Ueda +6 more
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Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease [PDF]
, 2017 Three-dimensional tissue-structural relationships are not well captured by typical thin-section histology, posing challenges for the study of tissue physiology and pathology. Moreover, while recent progress has been made with intact methods for clearing,
Arda, H. Efsun +14 more
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Tissue optical clearing mechanisms
, 2021 The high scattering and absorption of opaque tissues limit the penetration of light into deep tissues, limiting the imaging depth of various optical imaging techniques. The proposed tissue optical clearing technique provides an innovative way to perform deep-tissue imaging. Recently, various optical clearing methods have been developed.
Yu, T. +5 more
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Soft tissue tumors: Clear cell sarcoma [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on Soft tissue tumors: Clear cell sarcoma, with data on clinics, and the genes involved.
Poppe, Bruce +3 more
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Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow [PDF]
, 2017 Bone tissue harbors unique and essential physiological processes, such as hematopoiesis, bone growth, and bone remodeling. To enable visualization of these processes at the cellular level in an intact environment, we developed “Bone CLARITY,” a bone ...
Balani, Deepak H. +8 more
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Tissue clearing and imaging methods for cardiovascular development
iScience, 2021 Summary: Tissue imaging in 3D using visible light is limited and various clearing techniques were developed to increase imaging depth, but none provides universal solution for all tissues at all developmental stages. In this review, we focus on different
Hana Kolesová +4 more
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Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology? [PDF]
, 2017 Mammalian organs comprise a variety of cells that interact with each other and have distinct biological roles. Access to evaluate and perturb intact biological systems at the cellular and molecular levels is essential to fully understand their ...
Challis, Collin +3 more
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Serial optical coherence microscopy for label-free volumetric histopathology [PDF]
, 2020 The observation of histopathology using optical microscope is an essential procedure for examination of tissue biopsies or surgically excised specimens in biological and clinical laboratories.
A Azaripour +33 more
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Three-Dimensional Virtual Optical Clearing With Cycle-Consistent Generative Adversarial Network
Frontiers in Physics, 2022 High-throughput deep tissue imaging and chemical tissue clearing protocols have brought out great promotion in biological research. However, due to uneven transparency introduced by tissue anisotropy in imperfectly cleared tissues, fluorescence imaging ...
Jiajia Chen +8 more
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