Results 51 to 60 of about 3,009,910 (332)

Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.-Ham. ex D. Don extracts

Frontiers in Pharmacology, 2022
Background: Combination of Polygonum capitatum Buch.-Ham. ex D. Don extract (PCE) and ciprofloxacin (CIP) was commonly prescribed in the treatment of urinary tract infections. Their pharmacokinetic herb-drug interactions (HDIs) were focused in this study
Ziqiang Li, Xi Du, Shuang Tian, Shanshan Fan, Xurui Zuo, Yanfen Li, Ruihua Wang, Baohe Wang, Yuhong Huang   +8 more
doaj   +1 more source

Bioadditive manufacturing of hybrid tissue scaffolds for controlled release kinetics [PDF]

, 2012
Development of engineered tissue scaffolds with superior control over cell-protein interactions is still very much infancy. Advancing through heterogeneous multifold scaffolds with controlled release fashion enables synchronization of regenerating tissue
Khoda, AKMB, Koç, Bahattin, Özbolat, İbrahim T.   +2 more
core   +1 more source

New Insights Into the Evolution of Corticotropin-Releasing Hormone Family With a Special Focus on Teleosts

Frontiers in Endocrinology, 2022
Corticotropin-releasing hormone (CRH) was discovered for its role as a brain neurohormone controlling the corticotropic axis in vertebrates. An additional crh gene, crh2, paralog of crh (crh1), and likely resulting from the second round (2R) of ...
Gersende Maugars, Gersende Maugars, Xavier Mauvois, Patrick Martin, Salima Aroua, Karine Rousseau, Sylvie Dufour   +6 more
doaj   +1 more source

Occurrence, Profile, and Potential Risks of Novel and Legacy Polyfluoroalkyl Substances in Bullfrogs: Pilot Study in an Intensive Aquaculture Region, China

Frontiers in Environmental Science, 2021
Per- and polyfluoroalkyl substances (PFASs) have captured worldwide attention due to their persistent and bioaccumulative characteristics. The bullfrog is a highly nutritious and edible aquatic product, but the PFAS accumulation characteristics of ...
Qiongping Sun, Yonglong Xiong, Ran Bi, Ran Bi, Xinyi Zhan, Yueyao Fan, Chuanghong Su, Zhenwei Chen, Zhao Zheng, Zhao Zheng, Jieyi Diao, Tieyu Wang   +11 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Global morphogenetic flow is accurately predicted by the spatial distribution of myosin motors. [PDF]

, 2018
During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding into specific shapes. While developmental biology has identified key genes and local cellular processes, global coordination of tissue remodeling at the organ scale ...
Lefebvre, Matthew F, Noll, Nicholas, Shraiman, Boris I, Streichan, Sebastian J, Wieschaus, Eric F   +4 more
core   +2 more sources

Infective SARS-CoV-2 in Skull Sawdust at Autopsy, Finland

Emerging Infectious Diseases
We assessed the distribution of SARS-CoV-2 at autopsy in 22 deceased persons with confirmed COVID-19. SARS-CoV-2 was found by PCR (2/22, 9.1%) and by culture (1/22, 4.5%) in skull sawdust, suggesting that live virus is present in tissues postmortem ...
Jonas N. Kantonen, Suvi Kuivanen, Teemu Smura, Henri Puttonen, Eliisa Kekäläinen, Antti Sajantila, Liisa Myllykangas, Anu Kantele, Olli Vapalahti, Mikko I. Mäyränpää, Olli Carpén   +10 more
doaj   +1 more source

Tissue Distribution, Pharmacokinetics, and Effect of Hematological and Biochemical Parameters of Acute Intravenous Administration of Silver Nanoparticles in Rats

Nanomaterials, 2023
The widespread biomedical and commercial applications of silver nanoparticles (AgNPs) have increased their potential for human and environmental exposure and toxicity to human health.
Elsayed I. Salim, Khaled Y. Abdel-Halim, Mostafa E. El-Mahalawy, Haitham A. Badr, Hafiz Ahmed   +4 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source