Results 51 to 60 of about 12,729,869 (376)

Pharmacokinetics, Tissue Distribution and Excretion of a Novel Diuretic (PU-48) in Rats

Pharmaceutics, 2018
Methyl 3-amino-6-methoxythieno [2,3-b] quinoline-2-carboxylate (PU-48) is a novel diuretic urea transporter inhibitor. The aim of this study is to investigate the profile of plasma pharmacokinetics, tissue distribution, and excretion by oral dosing of PU-
Zhi-Yuan Zhang, Hua Zhang, Dan Liu, Ying-Yuan Lu, Xin Wang, Pu Li, Ya-Qing Lou, Bao-Xue Yang, Ya-Xin Lou, Chuang Lu, Qiang Zhang, Guo-Liang Zhang   +11 more
doaj   +1 more source

Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Naringin in Aged Rats

Frontiers in Pharmacology, 2019
Aging is an inevitable biological process characterized by the loss of functional capacity and associated with changes in all phases of pharmacokinetic processes. Naringin, a dietary flavanone glycoside, has been proved to be beneficial for the treatment
Xuan Zeng, Weiwei Su, Yuying Zheng, Yudong He, Yan He, Hong-yu Rao, W. Peng, Hongliang Yao   +7 more
semanticscholar   +1 more source

Expression, Tissue Distribution and Function of miR-21 in Esophageal Squamous Cell Carcinoma [PDF]

, 2013
Objective:MiR-21 is an oncomir expressed by malignant cells and/or tumor microenvironment components. In this study we focused on understanding the effects of stromal miR-21 on esophageal malignant cells.Design:MiR-21 expression was evaluated in formalin-
Calin, G.A., Mowla, S.J., Naghshvar, F., Nouraee, N., Omidi, A.A., Samaei, N.M., Semnani, S., Van Roosbroeck, K., Vasei, M.   +8 more
core   +3 more sources

Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution

Drug Delivery, 2019
Lycopene is considered as a promising neuroprotector with multiple bioactivities, while its therapeutic use in neurological disorders is restricted due to low solubility, instability and limited bioavailability.
Yunliang Guo, Xuyan Mao, Jing Zhang, Peng Sun, Haiyang Wang, Yue Zhang, Yingjuan Ma, Song Xu, Renjun Lv, Xueping Liu   +9 more
doaj   +1 more source

Pharmacokinetics, Tissue Distribution and Excretion of Isoalantolactone and Alantolactone in Rats after Oral Administration of Radix Inulae Extract

Molecules, 2015
Radix Inulae is endemic to China and has been used in traditional medicine to treat upper body pain, emesis and diarrhoea, and to eliminate parasites. Here, an UPLC-MS/MS method was developed and applied to study the pharmacokinetics, distribution and ...
Renjie Xu, Guisheng Zhou, Ying Peng, Mengyue Wang, Xiaobo Li   +4 more
doaj   +1 more source

Bioadditive manufacturing of hybrid tissue scaffolds for controlled release kinetics [PDF]

, 2012
Development of engineered tissue scaffolds with superior control over cell-protein interactions is still very much infancy. Advancing through heterogeneous multifold scaffolds with controlled release fashion enables synchronization of regenerating tissue
Khoda, AKMB, Koç, Bahattin, Özbolat, İbrahim T.   +2 more
core   +1 more source

Pharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat

BioMed Research International, 2017
Icariin is one of the predominant flavonoids contained in Herba Epimedii (Yin-yang-huo in Chinese), a well-known Chinese medicine for the treatment of cancers and immune system diseases. Although Herba Epimedii has been widely used in China and there are
Shun-jun Xu, Jie-jing Yu, Jing-jing Zhan, Liu Yang, Longgang Guo, Yi-juan Xu   +5 more
semanticscholar   +1 more source

Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases

Drug Design, Development and Therapy, 2020
Oscar Ekpenyong, Xiuqing Gao, Jing Ma, Candace Cooper, Linh Nguyen, Omonike A Olaleye, Dong Liang, Huan Xie Department of Pharmaceutical and Environmental Health Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX ...
Ekpenyong O, Gao X, Ma J, Cooper C, Nguyen L, Olaleye OA, Liang D, Xie H   +7 more
doaj  

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

Journal of Immunology, 1986
ICAM-1 is a cell surface glycoprotein originally defined by a monoclonal antibody (MAb) that inhibits phorbol ester-stimulated leukocyte aggregation. Staining of frozen sections and immunofluorescence flow cytometry showed intercellular adhesion molecule-
Michael Loran Dustin, R. Rothlein, A. Bhan, C. Dinarello, T. Springer   +4 more
semanticscholar   +1 more source

Eigenspectra optoacoustic tomography achieves quantitative blood oxygenation imaging deep in tissues

, 2015
Light propagating in tissue attains a spectrum that varies with location due to wavelength-dependent fluence attenuation by tissue optical properties, an effect that causes spectral corruption.
Bayer, Christine, Glasl, Sarah, Multhoff, Gabriele, Ntziachristos, Vasilis, Nunes, Antonio, Olefir, Ivan, Stangl, Stefan, Symvoulidis, Panagiotis, Tzoumas, Stratis   +8 more
core   +1 more source