Results 61 to 70 of about 12,729,869 (376)

Distribution of thymic tissue in the mediastinal adipose tissue

The Journal of Thoracic and Cardiovascular Surgery, 1991
The distribution of thymic tissue in the anterior mediastinal, retrocarinal, and preaortic fat was examined histologically in 27 autopsy subjects. Thymic tissue was found in the anterior mediastinal fat in 12 subjects (44.4%), in the retrocarinal fat in two (7.4%), and in the preaortic fat in none.
I, Fukai, Y, Funato, T, Mizuno, T, Hashimoto, A, Masaoka   +4 more
openaire   +2 more sources

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor

mAbs, 2016
MPDL3280A is a human monoclonal antibody that targets programmed cell death-1 ligand 1 (PD-L1), and exerts anti-tumor activity mainly by blocking PD-L1 interaction with programmed cell death-1 (PD-1) and B7.1.
R. Deng, Daniela Bumbaca, Cinthia V. Pastuskovas, C. Boswell, David West, K. Cowan, H. Chiu, J. McBride, Clarissa Johnson, Y. Xin, H. Koeppen, M. Leabman, S. Iyer   +12 more
semanticscholar   +1 more source

Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions

Frontiers in Pharmacology, 2019
The pharmacokinetic profile of a drug can be different when delivered as a nanosuspension compared with a true solution, which may in turn affect the therapeutic effect of the drug.
Qi Yuan, Yanling Wang, Rufeng Song, Xianqiao Hou, Keke Yu, Jiaojiao Zheng, Juanmei Zhang, Xiaohui Pu, Jihong Han, Lanlan Zong   +9 more
doaj   +1 more source

Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.-Ham. ex D. Don extracts

Frontiers in Pharmacology, 2022
Background: Combination of Polygonum capitatum Buch.-Ham. ex D. Don extract (PCE) and ciprofloxacin (CIP) was commonly prescribed in the treatment of urinary tract infections. Their pharmacokinetic herb-drug interactions (HDIs) were focused in this study
Ziqiang Li, Xi Du, Shuang Tian, Shanshan Fan, Xurui Zuo, Yanfen Li, Ruihua Wang, Baohe Wang, Yuhong Huang   +8 more
doaj   +1 more source

Influence of molecular size on tissue distribution of antibody fragments

mAbs, 2016
Biodistribution coefficients (BC) allow estimation of the tissue concentrations of proteins based on the plasma pharmacokinetics. We have previously established the BC values for monoclonal antibodies.
Zhe Li, B. Krippendorff, Sharad K Sharma, A. Walz, T. Lavé, D. Shah   +5 more
semanticscholar   +1 more source

New Insights Into the Evolution of Corticotropin-Releasing Hormone Family With a Special Focus on Teleosts

Frontiers in Endocrinology, 2022
Corticotropin-releasing hormone (CRH) was discovered for its role as a brain neurohormone controlling the corticotropic axis in vertebrates. An additional crh gene, crh2, paralog of crh (crh1), and likely resulting from the second round (2R) of ...
Gersende Maugars, Gersende Maugars, Xavier Mauvois, Patrick Martin, Salima Aroua, Karine Rousseau, Sylvie Dufour   +6 more
doaj   +1 more source

Occurrence, Profile, and Potential Risks of Novel and Legacy Polyfluoroalkyl Substances in Bullfrogs: Pilot Study in an Intensive Aquaculture Region, China

Frontiers in Environmental Science, 2021
Per- and polyfluoroalkyl substances (PFASs) have captured worldwide attention due to their persistent and bioaccumulative characteristics. The bullfrog is a highly nutritious and edible aquatic product, but the PFAS accumulation characteristics of ...
Qiongping Sun, Yonglong Xiong, Ran Bi, Ran Bi, Xinyi Zhan, Yueyao Fan, Chuanghong Su, Zhenwei Chen, Zhao Zheng, Zhao Zheng, Jieyi Diao, Tieyu Wang   +11 more
doaj   +1 more source

Tensin1 expression and function in chronic obstructive pulmonary disease [PDF]

, 2019
open access articleChronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a non-synonymous SNP in ...
Amrani, Y., Bradding, Peter, Brightling, C. E., Clark, K., Gooptu, B., Roach, K.M., Smallwood, Dawn T., Stylianou, P.   +7 more
core   +1 more source

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Infective SARS-CoV-2 in Skull Sawdust at Autopsy, Finland

Emerging Infectious Diseases
We assessed the distribution of SARS-CoV-2 at autopsy in 22 deceased persons with confirmed COVID-19. SARS-CoV-2 was found by PCR (2/22, 9.1%) and by culture (1/22, 4.5%) in skull sawdust, suggesting that live virus is present in tissues postmortem ...
Jonas N. Kantonen, Suvi Kuivanen, Teemu Smura, Henri Puttonen, Eliisa Kekäläinen, Antti Sajantila, Liisa Myllykangas, Anu Kantele, Olli Vapalahti, Mikko I. Mäyränpää, Olli Carpén   +10 more
doaj   +1 more source