Results 251 to 260 of about 948,853 (295)
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Tissue Factor Pathway Inhibitor
Thrombosis and Haemostasis, 1995After intravenous and subcutaneous injection, heparins and low-molecular-weight heparins release tissue factor pathway inhibitor (TFPI) into the blood stream. Protamine immediately reverses the plasma levels of TFPI to pretreatment values. A low-molecular-weight dermatan sulphate releases only very small amounts of TFPI after intravenous injection ...
J, Harenberg, R, Malsch, D L, Heene
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Tissue Factor Pathway Inhibitor Endocytosis
Trends in Cardiovascular Medicine, 1997Tissue factor pathway inhibitor (TFPI), a 42 kD protein, provides the physiological inhibition of tissue factor initiated coagulation by inhibition of both factor Xa and factor VIIa/tissue factor. In plasma, most TFPI is lipoprotein bound with an additional "releasable" pool bound to the endothelial cell surface. TFPI clearance is via receptor mediated
A L, Schwartz, G J, Broze
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Tissue factor pathway inhibitor in atherosclerosis
Clinica Chimica Acta, 2019Tissue factor pathway inhibitor (TFPI) reduces the development of atherosclerosis by regulating tissue factor (TF) mediated coagulation pathway. In this review, we focus on recent findings on the inhibitory effects of TFPI on endothelial cell activation, vascular smooth muscle cell (VSMC) proliferation and migration, inflammatory cell recruitment and ...
Hou-Qin, Yuan +10 more
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Tissue factor pathway inhibitor.
Minerva medica, 1999The role of Tissue Factor (TF, thromboplastin) as the major factor in initiation of the blood coagulation process has been known for more than 100 years. Its importance for the development of clinical thrombosis, be it venous or arterial, and the complexity of the cell biology of TF, have however been increasingly appreciated over the past 15-20 years.
CAMICI, MARCELLO, SAGRIPANTI A.
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[Tissue factor pathway inhibitors].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2002Activation of the extrinsic pathway of blood coagulation plays the key role in the process of blood coagulation. The hemostasis is influenced by the activity of procoagulant factors and its inhibitors. In this work we summarize existing data on tissue factor pathway inhibitors: TFPI and TFPI-2.
Ewa, Sierko +2 more
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Tissue Factor and Tissue Factor Pathway Inhibitor in Hemodialysis Patients
The International Journal of Artificial Organs, 1998Tissue factor and tissue factor pathway inhibitor are important in extrinsic coagulation. We investigated their clinical significance in hemodialysis patients. We took blood samples, prior to initiation of routine hemodialysis, from 73 patients on hemodialysis (35 men and 38 women aged 56.1 ± 11.7 years on dialysis for 82.1 ± 61.0 months), and ...
N, Yorioka +6 more
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Tissue Factor Pathway Inhibitor: Then and Now
Seminars in Thrombosis and Hemostasis, 2014Tissue factor pathway inhibitor (TFPI) is the major physiological regulator of tissue factor (TF)-induced blood coagulation. TFPI inhibits the TF-activated factor VII (FVIIa) complex in an activated factor X (FXa)-dependent manner, helping to control thrombin generation and ultimately fibrin formation.
Ellery, P., Adams, M.
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Tissue Factor Pathway Inhibitor: Potential Therapeutic Applications
Thrombosis and Haemostasis, 1997Tissue factor pathway of coagulation plays a dominant role during normal haemostasis. Tissue factor pathway inhibitor (TFPI), expressed primarily by the microvascular endothelium, appears to be the major physiologic inhibitor of TF-induced coagulation.
M S, Bajaj, S P, Bajaj
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Tissue Factor Pathway Inhibitor and Heparin
1992The anticoagulant property of heparinized blood results from interactions between heparin, protease inhibitors and clotting enzymes. The inactivation of thrombin, factor Xa and factor IXa by antithrombin (AT) is dramatically accelerated by even low concentrations of heparin.
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Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor
Journal of Thrombosis and Thrombolysis, 2012Preeclampsia (PE) is a multi-system disorder of human pregnancy, whose etiology remains poorly understood. Preeclamptic women are known to have an increased hypercoagulable state that result in excess fibrin deposition in several organs, which compromises their function.
Godoi, Lara Carvalho +5 more
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