Gla-domainless factor Xa: molecular bait to bypass a blocked tenase complex
Haematologica, 2012 Background Hemophilia is caused by deficiencies in coagulation factor VIII or IX, resulting in direct blockade of the intrinsic tenase complex and indirect blockade of the extrinsic tenase complex which is rapidly inhibited upon binding of factor Xa to ...
Raphaël Marlu, Benoît Polack
doaj +1 more source
Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]
, 2015 Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng +5 more
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Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. [PDF]
, 2010 The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that define
A Bianchini +60 more
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The abnormalities of coagulation and fibrinolysis in acute lung injury caused by gas explosion
Kaohsiung Journal of Medical Sciences, 2020 Acute lung injury (ALI) caused by gas explosion is common, and warrants research on the underlying mechanisms. Specifically, the role of abnormalities of coagulation and fibrinolysis in this process has not been defined.
Lin‐Qiang Tian +14 more
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Frontiers in Oncology, 2020 Factor V (FV) is a critical component in the blood coagulation cascade. In patients, FV inhibitors have been reported to be associated with malignancy. FV is present in plasma and platelets, which exhibit physical and functional differences. However, the
Xin Deng +18 more
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Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI. [PDF]
PLoS ONE, 2016 Factor (F) XI supports both normal human hemostasis and pathological thrombosis. Activated FXI (FXIa) promotes thrombin generation by enzymatic activation of FXI, FIX, FX, and FV, and inactivation of alpha tissue factor pathway inhibitor (TFPIα), in ...
Cristina Puy +7 more
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The role of coagulation hemostasis for development of early-onset preeclampsia in low-risk patients
Акушерство, гинекология и репродукция, 2022 Aim: to determine a role of specific parameters of coagulation hemostasis for development of severe early-onset preeclampsia (еPE) in low-risk patients.Materials and Methods.
M. G. Nikolaeva +4 more
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GBM radiosensitizers: dead in the water…or just the beginning? [PDF]
, 2017 The finding that most GBMs recur either near or within the primary site after radiotherapy has fueled great interest in the development of radiosensitizers to enhance local control.
Bindra, Ranjit S. +3 more
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Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]
, 2015 Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
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Multiple gene aberrations and breast cancer: lessons from super-responders. [PDF]
, 2015 BackgroundThe presence of multiple molecular aberrations in patients with breast cancer may correlate with worse outcomes.Case presentationsWe performed in-depth molecular analysis of patients with estrogen receptor-positive, HER2-negative, hormone ...
Atkins, Johnique T +6 more
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