Results 41 to 50 of about 1,251,677 (333)

The role of coagulation hemostasis for development of early-onset preeclampsia in low-risk patients

open access: yesАкушерство, гинекология и репродукция, 2022
Aim: to determine a role of specific parameters of coagulation hemostasis for development of severe early-onset preeclampsia (еPE) in low-risk patients.Materials and Methods.
M. G. Nikolaeva   +4 more
doaj   +1 more source

Multiple gene aberrations and breast cancer: lessons from super-responders. [PDF]

open access: yes, 2015
BackgroundThe presence of multiple molecular aberrations in patients with breast cancer may correlate with worse outcomes.Case presentationsWe performed in-depth molecular analysis of patients with estrogen receptor-positive, HER2-negative, hormone ...
Atkins, Johnique T   +6 more
core   +2 more sources

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]

open access: yes, 2009
The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S   +2 more
core   +1 more source

Concizumab, an anti‐tissue factor pathway inhibitor antibody, induces increased thrombin generation in plasma from haemophilia patients and healthy subjects measured by the thrombin generation assay

open access: yesHaemophilia, 2017
Concizumab, a humanized monoclonal antibody against tissue factor pathway inhibitor (TFPI), is being developed as a subcutaneously (s.c.) administered treatment for haemophilia.
E. K. Waters   +4 more
semanticscholar   +1 more source

Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer. [PDF]

open access: yes, 2016
The poor prognosis for patients with inflammatory breast cancer (IBC) compared to patients with other types of breast cancers emphasizes the need to better understand the molecular underpinnings of this disease with the goal of developing effective ...
Boerner, Julie   +11 more
core   +2 more sources

MiR‐616‐3p modulates cell proliferation and migration through targeting tissue factor pathway inhibitor 2 in preeclampsia

open access: yesCell Proliferation, 2018
Despite improvements in diagnosis and treatment, preeclampsia (PE) continues to pose a significant risk of maternal and foetal morbidity and mortality if not addressed promptly.
Yetao Xu   +10 more
semanticscholar   +1 more source

Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/β-catenin signaling [PDF]

open access: yes, 2012
Tissue inhibitor of metalloproteinases 1 (TIMP-1) is a matrix metalloproteinase (MMP)-independent regulator of growth and apoptosis in various cell types.
Avalos   +42 more
core   +1 more source

Research progress on clinical application of anti-tissue factor pathway inhibitor in hemophilia [PDF]

open access: yesZhenduanxue lilun yu shijian
In recent years, to address the unmet needs in hemophilia treatment, significant research has led to unprecedented advances in pharmacotherapy, including the development of several innovative mechanism-based therapies that restore hemostatic balance by ...
XIAO Jianwen, YI Weijia
doaj   +1 more source

Factor V‐short and protein S as synergistic tissue factor pathway inhibitor (TFPIα) cofactors

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2017
Essentials FV‐Short, a normal splice isoform of Factor V, binds tissue factor pathway inhibitor (TFPIα) with high affinity. FV‐Short functions as a synergistic TFPIα cofactor with protein S in inhibition of Factor Xa.
B. Dahlbäck   +3 more
semanticscholar   +1 more source

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas [PDF]

open access: yes, 2018
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with ...
Abdel-Rahman, Mohamed H.   +784 more
core   +2 more sources

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