Results 171 to 180 of about 84,021 (262)

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Maternal Infection Impairs Motor Coordination in an Experimental Meningitis Rat Model Through Altered MMP-2/3/9 Activity, H3K4 Trimethylation, and <i>Reln</i> Methylation. [PDF]

Int J Mol Sci
Surya TS, Sowndharya S, Sivamaruthi BS, Chaiyasut C, Rajan KE.   +4 more
europepmc   +1 more source

M2 Macrophage‐Mimetic and ROS‐Sensitive Hybrid Nanoplatform for Targeted Alleviation of Rheumatoid Arthritis

Exploration, EarlyView.
Rheumatoid arthritis (RA) is the most prevalent inflammatory arthropathy globally and remains incurable nowadays. Herein, an M2 macrophage‐mimetic hybrid nanoplatform (Cel@M2‐L‐MSN) is constructed for concerted RA therapy through joint‐specific accumulation, on‐demand drug release, inflammation resolution, ROS clearance, along with macrophage ...
Yi Xiao, Shiyu Meng, Zhuang Tang, Yonghang Liu, Xican Zhang, Kefan Wu, Yuanhao Liu, Ao Li, Jingyao Feng, Kaixiang Zhou, Hui Guo, Xiaolin Wang   +11 more
wiley   +1 more source

Inflammatory cytokine IL-6 regulates ADAMTS14 expression through MAPK and PI3K signaling in colorectal cancer. [PDF]

J Cell Commun Signal
Hacioglu N, Vapur Ondul RN, Ismael GH, Kockar F.   +3 more
europepmc   +1 more source

An Ocular Surface‐Targeting Nucleic Acid Hydrogel for Efficient Dry Eye Disease Treatment

Exploration, EarlyView.
A self‐assembled nucleic acid hydrogel modified with mucin‐1 (MUC1) aptamer is developed, which can actively target the mucin layer on the ocular surface and significantly extend its retention time after distillation. Inside the hydrogel, therapeutic siRNA is embedded and can effectively silence the inflammation gene expression, subsequently restoring ...
Yuhe Liu, Zimeng Zhai, Yangyang Huang, Fujun Wang, Zifei Wang, Lijuan Zhu, Ka Jiang, Xujiao Zhou, Xingtao Zhou, Ying Jie, Xiuming Jin, Chuan Zhang, Jiaxu Hong   +12 more
wiley   +1 more source

Association of MMP-9 and TIMP-1 concentration with neurological outcome after cardiac arrest and resuscitation - a substudy of the COMACARE trial. [PDF]

Resusc Plus
Kortesuo E, Tirkkonen J, Reinikainen M, Pekkarinen PT, Moilanen E, Petäjä L, Skrifvars MB, Hästbacka J.   +7 more
europepmc   +1 more source

Artificial Chlorella Biohybrids for Alleviation of Cartilage Degeneration in Osteoarthritis

Exploration, EarlyView.
Artificial Chlorella biohybrids (Ch@P) alleviate cartilage degeneration and protect against OA progression by activating mitophagy and reprogramming glucose metabolism in chondrocytes, as well as inducing articular thermal stimulation under near infrared irradiation.
Yongyun Chang, Keyu Kong, Minghao Jin, Shasha Liu, Yangzi Yang, Yingchun Zhu, Hua Qiao, Wenxuan Fan, Xinru Wu, Jingwei Zhang, Yansong Qi, Yongsheng Xu, Xiang Feng, Pingcuo Nima, Piting Ji, Tariel Mamuladze, Andrei A. Korytkin, Huiwu Li, Jingke Fu, Zanjing Zhai   +19 more
wiley   +1 more source

Matching TGF‐β1 Activation With Stress‐Responsive Charge‐Reversal Hydrogel Microspheres for the Treatment of Osteoarthritis

Exploration, EarlyView.
Based on the interaction between the weakly cross‐linked disulfide bonds that break under stress and charge‐reversal messenger molecules, we herein achieved nanoparticle charge reversal under stress and constructed a stress‐responsive charge‐reversal hydrogel microsphere system using microfluidic technology.
Feng Lin, Yiwen Xu, Lei Xiang, Yueliang Zhu, Yihan Li, Yaping Zhuang, Zengjie Zhang, Jiayu Chen, Heemin Kang, Ning Zhang, Xiaohua Yu, Wenguo Cui   +11 more
wiley   +1 more source

Lymphatic Malformations With Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases. [PDF]

Arterioscler Thromb Vasc Biol
Mastrogiacomo DM, Price A, Fu Y, Banerjee R, Knauer LA, Li K, Yang Y, Davis GE, Dellinger MT, Scallan JP.   +9 more
europepmc   +1 more source

Extracellular Vesicle‐Based Therapies for Osteoarthritis—Advances, Challenges and Hopes

Exploration, EarlyView.
Recent advances, challenges and hopes in using extracellular vesicles (EVs) as therapeutics for osteoarthritis. Recent advances include native and engineered EVs and translational developments. Challenges include cell sources and targeted effects of EVs, as well as establishing robust critical quality attributes, while hopes for advancing this field ...
Jiao Jiao Li, Wei Seong Toh
wiley   +1 more source