Results 221 to 230 of about 84,021 (262)
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Environmental and Molecular Mutagenesis, 2008
AbstractThe matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) may contribute to the development of adenomyosis. The aim of the present study was to investigate whether three single nucleotide polymorphisms (SNPs) in the promoter regions of MMP‐2 (−1306C/T and −735C/T) and TIMP‐2 (‐418G/C) genes were related to the risk
Shan, Kang +10 more
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AbstractThe matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) may contribute to the development of adenomyosis. The aim of the present study was to investigate whether three single nucleotide polymorphisms (SNPs) in the promoter regions of MMP‐2 (−1306C/T and −735C/T) and TIMP‐2 (‐418G/C) genes were related to the risk
Shan, Kang +10 more
openaire +2 more sources
Applied Immunohistochemistry & Molecular Morphology, 2022
Medullary Thyroid Carcinoma (MTC) is a tumor of the neuroendocrine system. In recent years, the need to assess the MTC diagnostic-related parameters has emerged with the aim to elucidate the mechanisms involved in this pathology. The objective of this study was to evaluate the role of Matrix Metalloproteinases (MMPs) 2 and 9, their tissue inhibitors of
Héctor Vázquez-Lorente +6 more
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Medullary Thyroid Carcinoma (MTC) is a tumor of the neuroendocrine system. In recent years, the need to assess the MTC diagnostic-related parameters has emerged with the aim to elucidate the mechanisms involved in this pathology. The objective of this study was to evaluate the role of Matrix Metalloproteinases (MMPs) 2 and 9, their tissue inhibitors of
Héctor Vázquez-Lorente +6 more
openaire +2 more sources
Matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in fetal rabbit lung
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2000Cell-extracellular matrix interaction and extracellular matrix remodeling are known to be important in fetal lung development. We investigated the localization of matrix metalloproteinases (MMPs) in fetal rabbit lungs. Immunohistochemistry for type IV collagen, MMP-1, MMP-2, MMP-9, membrane type (MT) 1 MMP, and tissue inhibitor of metalloproteinase ...
Y, Fukuda +4 more
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Molecular and Cellular Biochemistry, 2014
The aim of this study is to investigate the dynamic alterations of cardiac connexin 43 (Cx43), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the setting of different ventricular fibrillation (VF) duration. In this study, thirty-two dogs were randomly divided into sham control group, 8-min VF group, 12-min VF
Jing, Wang +6 more
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The aim of this study is to investigate the dynamic alterations of cardiac connexin 43 (Cx43), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the setting of different ventricular fibrillation (VF) duration. In this study, thirty-two dogs were randomly divided into sham control group, 8-min VF group, 12-min VF
Jing, Wang +6 more
openaire +2 more sources
Heart, Lung and Circulation, 2014
Doxorubicin (DOX) is a highly effective anti-cancer drug with limited clinical use due to its serious cardiotoxicity. Recent studies reported that erythropoietin (EPO) could exert a cardioprotective effect by non-erythropoietic effects. This study was to investigate fibrosis of DOX-induced cardiotoxicity and determine mechanisms of EPO against ...
Xing, Chen +3 more
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Doxorubicin (DOX) is a highly effective anti-cancer drug with limited clinical use due to its serious cardiotoxicity. Recent studies reported that erythropoietin (EPO) could exert a cardioprotective effect by non-erythropoietic effects. This study was to investigate fibrosis of DOX-induced cardiotoxicity and determine mechanisms of EPO against ...
Xing, Chen +3 more
openaire +2 more sources
Research in Veterinary Science, 2008
Matrix metalloproteinase-2 (MMP-2) and its inhibitor, tissue inhibitor of matrix metalloproteinase 2 (TIMP2), are known to be important in cancer. The purposes of this study were to determine the cDNA sequence of canine MMP-2 and to investigate the expression patterns of MMP-2 and TIMP2 in normal canine lymph nodes and spontaneously arising canine ...
R G, Newman +3 more
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Matrix metalloproteinase-2 (MMP-2) and its inhibitor, tissue inhibitor of matrix metalloproteinase 2 (TIMP2), are known to be important in cancer. The purposes of this study were to determine the cDNA sequence of canine MMP-2 and to investigate the expression patterns of MMP-2 and TIMP2 in normal canine lymph nodes and spontaneously arising canine ...
R G, Newman +3 more
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Endothelium, 2006
There are conflicting data in the literature regarding the expression pattern of the vascular matrix metalloproteinase (MMP) system and their inhibitors (TIMPs) in human hypertension. The authors hypothesized that MMP-2, MMP-9, and TIMP-1 would be abnormal in hypertension, reflecting alterations in extracellular matrix (ECM) turnover.
Derosa G. +12 more
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There are conflicting data in the literature regarding the expression pattern of the vascular matrix metalloproteinase (MMP) system and their inhibitors (TIMPs) in human hypertension. The authors hypothesized that MMP-2, MMP-9, and TIMP-1 would be abnormal in hypertension, reflecting alterations in extracellular matrix (ECM) turnover.
Derosa G. +12 more
openaire +4 more sources
Liver, 1997
Abstract: Serum levels of tissue inhibitor of metalloproteinases‐2 (TIMP2) and of precursor form of matrix metalloproteinase‐2 (proMMP2) were determined in patients with chronic hepatitis and hepatocellular carcinoma by a one‐step sandwich enzyme immunoassay.
M, Ebata +5 more
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Abstract: Serum levels of tissue inhibitor of metalloproteinases‐2 (TIMP2) and of precursor form of matrix metalloproteinase‐2 (proMMP2) were determined in patients with chronic hepatitis and hepatocellular carcinoma by a one‐step sandwich enzyme immunoassay.
M, Ebata +5 more
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Tissue inhibitor of matrix metalloproteinase-2 in nasopharyngeal carcinoma.
MedGenMed : Medscape general medicine, 2008By regulating matrix metalloproteinase (MMP) activity and controlling the breakdown of extracellular matrix components, tissue inhibitors of metalloproteinases (TIMPs) play an important role in the process of tumor invasion and metastasis. The present study was designed to clarify the role of TIMP-2 in nasopharyngeal carcinoma (NPC) patients and to ...
Amr Ahmed, El Badry +2 more
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Wound Repair and Regeneration, 2007
ABSTRACTThe involvement of gelatinase (matrix metalloproteinase‐2 [MMP‐2] and MMP‐9) in the matrix remodeling and development of tubulointerstitial fibrosis has been studied recently, but relatively little is known about the regulators and the mechanisms controlling the activation and expression of gelatinase in renal fibroblasts. In these studies, the
Min, Yang +4 more
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ABSTRACTThe involvement of gelatinase (matrix metalloproteinase‐2 [MMP‐2] and MMP‐9) in the matrix remodeling and development of tubulointerstitial fibrosis has been studied recently, but relatively little is known about the regulators and the mechanisms controlling the activation and expression of gelatinase in renal fibroblasts. In these studies, the
Min, Yang +4 more
openaire +2 more sources