Results 1 to 10 of about 157,447 (201)

The Contribution of Tissue Inhibitor of Metalloproteinase-2 Genotypes to Breast Cancer Risk in Taiwan [PDF]

Life, 2023
Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an endogenous inhibitor of matrix metalloproteinase-2 and is highly expressed in breast cancer (BC) cases at diagnosis.
Yun-Chi Wang, Jie-Long He, Chung-Lin Tsai, Huey-En Tzeng, Wen-Shin Chang, Shih-Han Pan, Li-Hsiou Chen, Chen-Hsien Su, Jiunn-Cherng Lin, Chih-Chiang Hung, Da-Tian Bau, Chia-Wen Tsai   +11 more
doaj   +2 more sources

The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs [PDF]

Pulmonary Medicine, 2022
Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous proteins that primarily function to inhibit the activities of proteases such as the matrix metalloproteinases (MMP).
Louis Costanzo, Brian Soto, Richard Meier, Patrick Geraghty   +3 more
doaj   +2 more sources

Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients. [PDF]

J Thorac Dis, 2017
Assessment of serum extracellular matrix (ECM) metalloproteinase MMP-2 and tissue inhibitor of matrix metalloproteinase TIMP-2 concentrations in non-small cell lung carcinoma (NSCLC) patients considering TNM staging. Assessment of the prognostic value of MMP-2 and TIMP-2 concentrations in NSCLC patients.The study group consisted of 81 NSCLC patients ...
Drzewiecka-Jędrzejczyk M, Wlazeł R, Terlecka M, Jabłoński S.   +3 more
europepmc   +4 more sources

Tissue inhibitor of metalloproteinase-2 predicts early allograft dysfunction after liver transplantation [PDF]

European Journal of Medical Research
Background The lack of objective criteria to assess graft integrity represents a major impediment to the acceptance of livers of limited quality as a way to increase the donor pool in liver transplantation.
Charlotte von Horn, Hristo Zlatev, Laura Malkus, Thomas Minor   +3 more
doaj   +2 more sources

Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder [PDF]

Mediators of Inflammation, 2019
The imbalance between MMPs and TIMPs is associated with the HIV dissemination tissue damage pathology neurodegenerative disorders, including HAND. Genetic variations in the TIMP gene may modulate the neurocognitive disorder in HIV patients.
HariOm Singh, Sushma Jadhav, Dharmesh Samani, Sumitra Nain   +3 more
doaj   +2 more sources

Mitral tissue inhibitor of metalloproteinase 2 is associated with mitral valve surgery outcome. [PDF]

PLoS ONE, 2014
BACKGROUND: Matrix metalloproteinases play a role in regulating cardiac remodeling. We previously reported an association between tissue inhibitor of metalloproteinase 2 (TIMP-2) expression and mitral valve (MV) disease.
Tsung-Hsien Lin, Sheau-Fang Yang, Chaw-Chi Chiu, Ho-Ming Su, Wen-Chol Voon, Chee-Yin Chai, Wen-Ter Lai, Sheng-Hsiung Sheu   +7 more
doaj   +2 more sources

Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension. [PDF]

J Clin Hypertens (Greenwich), 2016
Resistant hypertension (RH) is associated with organ damage and cardiovascular risk. Evidence suggests the involvement of matrix metalloproteinase 2 (MMP‐2) and tissue inhibitor of metalloproteinase 2 (TIMP‐2) in hypertension and in cardiovascular remodeling. The aim of this study was to assess the levels of MMP‐2 and TIMP‐2 in RH and its relation with
Sabbatini AR, Barbaro NR, de Faria AP, Modolo R, Ritter AM, Pinho C, Amorim RF, Fontana V, Moreno H.   +8 more
europepmc   +5 more sources

Release of tissue inhibitor of metalloproteinase-2 from alginate microcapsule encapsulating genetically engineered cells [PDF]

International Journal of Nanomedicine, 2013
Yeon Seong Kim,1,* Young-Il Jeong,2,* Shu-Guang Jin,2 Jian Pei,2 Min Wen,2 In-Young Kim,1 Kyung-Sub Moon,1 Tae-Young Jung,1 Hyang-Hwa Ryu2, Shin Jung1–3 1Department of Neurosurgery, 2Brain Tumor Research Laboratory, 3Chonnam National University ...
Kim YS, Jeong YI, Jin SG, Pei J, Wen M, Kim IY, Moon KS, Jung TY, Ryu HH, Jung S   +9 more
doaj   +2 more sources

Tissue Inhibitor of Metalloproteinase-2 Suppresses Collagen Synthesis in Cultured Keloid Fibroblasts. [PDF]

Plast Reconstr Surg Glob Open, 2015
Keloids are defined as a kind of dermal fibroproliferative disorder resulting from the accumulation of collagen. In the remodeling of extracellular matrix, the balance between matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) is as critical as the proper production of extracellular matrix.
Dohi T, Miyake K, Aoki M, Ogawa R, Akaishi S, Shimada T, Okada T, Hyakusoku H.   +7 more
europepmc   +3 more sources

Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironment. [PDF]

Mol Cell Ther, 2014
There has been a recent paradigm shift in the way we target cancer, drawing a greater focus on the role of the tumor microenvironment (TME) in cancer development, progression and metastasis. Within the TME, there is a crosstalk in signaling and communication between the malignant cells and the surrounding extracellular matrix. Matrix metalloproteinases
Remillard TC, Bratslavsky G, Jensen-Taubman S, Stetler-Stevenson WG, Bourboulia D.   +4 more
europepmc   +4 more sources