The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs [PDF]
Pulmonary Medicine, 2022 Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous proteins that primarily function to inhibit the activities of proteases such as the matrix metalloproteinases (MMP).
Louis Costanzo +3 more
doaj +5 more sources
The Contribution of Tissue Inhibitor of Metalloproteinase-2 Genotypes to Breast Cancer Risk in Taiwan [PDF]
Life, 2023 Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an endogenous inhibitor of matrix metalloproteinase-2 and is highly expressed in breast cancer (BC) cases at diagnosis.
Yun-Chi Wang +11 more
doaj +2 more sources
Tissue inhibitor of metalloproteinase-2 predicts early allograft dysfunction after liver transplantation [PDF]
European Journal of Medical ResearchBackground The lack of objective criteria to assess graft integrity represents a major impediment to the acceptance of livers of limited quality as a way to increase the donor pool in liver transplantation.
Charlotte von Horn +3 more
doaj +2 more sources
Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder [PDF]
Mediators of Inflammation, 2019 The imbalance between MMPs and TIMPs is associated with the HIV dissemination tissue damage pathology neurodegenerative disorders, including HAND. Genetic variations in the TIMP gene may modulate the neurocognitive disorder in HIV patients.
HariOm Singh +3 more
doaj +2 more sources
Mitral tissue inhibitor of metalloproteinase 2 is associated with mitral valve surgery outcome. [PDF]
PLoS ONE, 2014 BACKGROUND: Matrix metalloproteinases play a role in regulating cardiac remodeling. We previously reported an association between tissue inhibitor of metalloproteinase 2 (TIMP-2) expression and mitral valve (MV) disease.
Tsung-Hsien Lin +7 more
doaj +2 more sources
Biomolecules, 2019 Chronic obstructive pulmonary disease (COPD) is influenced by genetic and environmental factors. A protease-antiprotease imbalance has been suggested as a possible pathogenic mechanism for COPD.
Pelin Uysal, Hafize Uzun
doaj +3 more sources
The Continuing Saga of Tissue Inhibitor of Metalloproteinase 2: Emerging Roles in Tissue Homeostasis and Cancer Progression. [PDF]
Am J Pathol, 2023 Tissue inhibitors of metalloproteinases (TIMPs) are a conserved family of proteins that were originally identified as cytokine-like erythroid growth factors. Subsequently, TIMPs were characterized as endogenous inhibitors of matrixin proteinases. These proteinases are the primary mediators of extracellular matrix turnover in pathologic conditions, such
Stetler-Stevenson WG.
europepmc +3 more sources
Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients. [PDF]
J Thorac Dis, 2017 Assessment of serum extracellular matrix (ECM) metalloproteinase MMP-2 and tissue inhibitor of matrix metalloproteinase TIMP-2 concentrations in non-small cell lung carcinoma (NSCLC) patients considering TNM staging. Assessment of the prognostic value of MMP-2 and TIMP-2 concentrations in NSCLC patients.The study group consisted of 81 NSCLC patients ...
Drzewiecka-Jędrzejczyk M +3 more
europepmc +4 more sources
Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension. [PDF]
J Clin Hypertens (Greenwich), 2016 Resistant hypertension (RH) is associated with organ damage and cardiovascular risk. Evidence suggests the involvement of matrix metalloproteinase 2 (MMP‐2) and tissue inhibitor of metalloproteinase 2 (TIMP‐2) in hypertension and in cardiovascular remodeling. The aim of this study was to assess the levels of MMP‐2 and TIMP‐2 in RH and its relation with
Sabbatini AR +8 more
europepmc +5 more sources
Ratio of Metalloproteinase 2 to Tissue Inhibitor of Metalloproteinase 2 in Medullary Thyroid Carcinoma [PDF]
Archives of Otolaryngology–Head & Neck Surgery, 2009 To develop an index for the ratio of metalloproteinase 2 (MMP-2) to its tissue inhibitor (TIMP-2) in immunostained medullary thyroid carcinoma specimens and to correlate it with clinical and pathologic prognostic factors. Metalloproteinases, enzymes related to the degradation of the extracellular matrix, take part in carcinogenesis and have been ...
Beatriz Godoi, Cavalheiro +2 more
openaire +2 more sources