Results 191 to 200 of about 95,734 (211)

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

The Landscape of Biomarkers in ICU‐Associated AKI: From Protein Markers to Cell‐Free Nucleic Acids

Journal of Clinical Laboratory Analysis, EarlyView.
Acute kidney injury (AKI) in critically ill patients—particularly in sepsis—often develops early and is missed by creatinine/urine output–based criteria, delaying risk stratification and timely intervention. This review synthesizes current evidence on established and emerging AKI biomarkers (e.g., NGAL, KIM‐1, [TIMP‐2]·[IGFBP7]) alongside circulating ...
Qi Zhu, Feng Yang, Hua Zheng, Xinxin Guo, Zhijin Chen, Limin Chen, Daoli Wang, Jiaqi Wang, Xinmeng Wang, Zhiyuan Huang, Zhenhua Ji   +10 more
wiley   +1 more source

Melatonin Regulates Arylhydrocarbon Receptor Mediated UVR-Induced Processes Related to Inflammation, Skin Aging and Carcinogenesis in Human Ex Vivo Skin. [PDF]

Exp Dermatol
Pustelnik K, Burner T, Hoetzenecker W, Fischer TW.   +3 more
europepmc   +1 more source

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Methylation of the <i>BMP6</i>, <i>BRCA1</i>, <i>ESR2</i>, <i>GSTP1</i> and <i>TIMP3</i> genes in Mexican women with breast cancer and benign disease. [PDF]

Oncol Lett
de la Torre-Guzmán SR, García Muro AM, Pelayo-Chávez B, Vázquez-Gastélum C, Gallegos-Arreola MP, Soto-Reyes E, Meza-Chavolla SO, Sánchez-López JY.   +7 more
europepmc   +1 more source

Membrane-type I metalloproteinase (MT1-MMP): A key modifier of extracellular matrix microenvironment. [PDF]

FEBS J
Itoh Y, Inada M.
europepmc   +1 more source

MMP8 exacerbates sepsis-induced pulmonary vascular leakage by disruption of endothelial VE-cadherin through ERK signalling. [PDF]

Mol Biomed
Peng Y, Wu Q, Liu Y, Jing D, Bai Y, Zhu H.   +5 more
europepmc   +1 more source

Synovial Fluid Biomarkers Associated With Anterior Cruciate Ligament Injury and Reconstruction: A Systematic Review. [PDF]

Orthop J Sports Med
Touhey DC, Knapik DM, Tartibi S, Gopinatth V, Boghosian T, Matava MJ, Smith MV, Brophy RH.   +7 more
europepmc   +1 more source

HMGB1 Upregulates MMP-1-Mediated Mesothelial-Mesenchymal Transition and Promotes Pleural Fibrosis in Tuberculous Pleural Effusion. [PDF]

Int J Mol Sci
Chen WL, Lee KL, Chen MC, Hsiao SH, Chung CL.   +4 more
europepmc   +1 more source