Results 11 to 20 of about 153,944 (203)

The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microglia. [PDF]

J Neuroinflammation, 2014
Tissue inhibitors of metalloproteinases (TIMPs) are known to be endogenous inhibitors of matrix metalloproteinases (MMPs). Our preliminary study showed that TIMP-2 is constitutively expressed in microglia but significantly inhibited by lipopolysaccharide (LPS) treatment.
Lee EJ, Kim HS.
europepmc   +5 more sources

Prognostic value of tissue inhibitor of metalloproteinase-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis. [PDF]

PLoS ONE, 2015
Background and objectivesTissue inhibitor of metalloproteinase-2 (TIMP-2) is a small secretory glycoprotein with anti-matrix metalloproteinase activity.
Lin Zhu, Hong Yu, Shi-Yuan Liu, Xiang-Sheng Xiao, Wei-Hua Dong, Yi-Nan Chen, Wei Xu, Tong Zhu   +7 more
doaj   +2 more sources

Tissue Inhibitor of Metalloproteinases-2 Mediates Kidney Injury during Sepsis [PDF]

Nephron, 2020
<b><i>Introduction:</i></b> Urinary tissue inhibitor of metalloproteinases (TIMP)-2 has been identified as a predictive marker for acute kidney injury (AKI), including sepsis-associated AKI (S-AKI). Whether TIMP-2 might be causally related to AKI and hence represent a viable drug target is unclear.
Xiaoyan, Wen, Jicheng, Zhang, Xiaojian, Wan, Alicia A, Frank, Xin, Qu, John A, Kellum   +5 more
openaire   +2 more sources

Investigation of the relationship between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase with SARS CoV-2 infections

Journal of Advanced Biotechnology and Experimental Therapeutics, 2023
SARS-CoV-2 stands for severe acute respiratory syndrome coronavirus 2 which is the causative agent of spreading coronavirus disease 2019 that is known as COVID-19 pandemic, the disease leads to severe acute respiratory illness. Matrix metalloproteinases-
May K. Ismael, Lubna M. Rasuol, Yasir Basim Qaddoori   +2 more
doaj   +1 more source

The intestinal sutures insufficiency: factors of risk and prognostication, based on genetic investigations

Клінічна хірургія, 2022
Objective. To improve the results of treatment in patients, suffering insufficiency of sutures of intestinal anastomoses, using analysis of rate in the genes polymorphous variants of the matrix metalloproteinase Type 2 (C-1306 →T) and the tissue ...
O. Yu. Usenko, Ya. Yu. Voitiv
doaj   +1 more source

Ratio of Metalloproteinase 2 to Tissue Inhibitor of Metalloproteinase 2 in Medullary Thyroid Carcinoma [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2009
To develop an index for the ratio of metalloproteinase 2 (MMP-2) to its tissue inhibitor (TIMP-2) in immunostained medullary thyroid carcinoma specimens and to correlate it with clinical and pathologic prognostic factors. Metalloproteinases, enzymes related to the degradation of the extracellular matrix, take part in carcinogenesis and have been ...
Beatriz Godoi, Cavalheiro, Consuelo Rodrigues, Junqueira, Lenine Garcia, Brandão   +2 more
openaire   +2 more sources

Prognostic Values of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in Bladder Cancer [PDF]

The Journal of Urology, 1998
Matrix metalloproteinase-2 (MMP-2), which degrades the extracellular matrix or the basement membrane, has an essential role in tumor invasion and metastasis. To evaluate the roles of MMP-2, its inhibitor (tissue inhibitor of metalloproteinase-2 [TIMP-2]), and its activator (membrane-type matrix metalloproteinase-1 [MT1-MMP]) in tumor invasion or as a ...
H, Kanayama, K, Yokota, Y, Kurokawa, Y, Murakami, M, Nishitani, S, Kagawa   +5 more
openaire   +2 more sources

Salivary molecules of bone remodeling and tissue repair after head and neck radiotherapy

Brazilian Oral Research, 2021
Head and neck radiotherapy causes quantitative and qualitative changes in saliva. The objective of this case-control study was to evaluate the salivary biomarkers associated with bone remodeling and tissue repair in patients submitted to radiotherapy for
Eduardo Morato de OLIVEIRA, Rafael Soares GUIEIRO, Bárbara Lima CRUZ, Maria Cássia Ferreira de AGUIAR, Janine Mayra da SILVA, Tarcília Aparecida SILVA, Patrícia Carlos CALDEIRA   +6 more
doaj   +1 more source

The extracellular matrix degradation markers as predictors of left ventricular systolic dysfunction among patients with STEMI

Сучасні медичні технології, 2021
The purpose of the study. To determine predictor value of the extracellular matrix degradation markers relative to the occurrence of left ventricular systolic dysfunction among patients with STEMI determined. Materials and methods.
I. M. Fushtey, E. V. Sid
doaj   +1 more source

Clinical significance of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 and 2 in Kawasaki disease [PDF]

Korean Journal of Pediatrics, 2010
Purpose : Kawasaki disease (KD) is a systemic vasculitis, a leading cause of pediatric acquired heart disease. Histopathological findings of coronary artery lesion (CAL) in KD indicate destruction of the coronary artery wall with diffuse vasculitis ...
Ki Wook Yun, Sin Weon Sin, Jung Ju Lee, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Byoung Hoon Yoo, Mi-Kyung Lee   +7 more
doaj   +1 more source