Results 221 to 230 of about 66,322 (262)
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The Prostate, 1998
The balance between matrix metalloproteinases (MMP) and the tissue inhibitors of metalloproteinases (TIMP) has been seen as important during tumor invasion and progression. The determination of these components needs a special strategy of tissue preparation.
K, Jung +6 more
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The balance between matrix metalloproteinases (MMP) and the tissue inhibitors of metalloproteinases (TIMP) has been seen as important during tumor invasion and progression. The determination of these components needs a special strategy of tissue preparation.
K, Jung +6 more
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Tissue inhibitors of metalloproteinases in liver fibrosis
The International Journal of Biochemistry & Cell Biology, 1997Liver fibrosis and its end stage sequelae cirrhosis represent a major worldwide health problem. By definition progressive fibrosis occurs when the rate of matrix synthesis exceeds matrix degradation. Considerable evidence suggests that the hepatic stellate cell is central to the fibrotic process.
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Biological Chemistry, 2003
The matrix metalloproteinases (MMPs) constitute a family of multidomain zinc endopeptidases with a metzincin-like catalytic domain, which are involved in extracellular matrix degradation but also in a number of other important biological processes. Under healthy conditions, their proteolytic activity is precisely regulated by their main endogenous ...
Bode, W., Maskos, K.
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The matrix metalloproteinases (MMPs) constitute a family of multidomain zinc endopeptidases with a metzincin-like catalytic domain, which are involved in extracellular matrix degradation but also in a number of other important biological processes. Under healthy conditions, their proteolytic activity is precisely regulated by their main endogenous ...
Bode, W., Maskos, K.
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1996
Matrix metalloproteinases (MMPs), also termed “matrixins”, constitute a family of zinc metalloendopeptidases that participate in breakdown of extracellular matrix macromolecules (Woessner, 1991). These enzymes are considered to play an important role in many biological processes such as in reproduction, embryogenesis, tissue resorption, and in the ...
H, Nagase +6 more
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Matrix metalloproteinases (MMPs), also termed “matrixins”, constitute a family of zinc metalloendopeptidases that participate in breakdown of extracellular matrix macromolecules (Woessner, 1991). These enzymes are considered to play an important role in many biological processes such as in reproduction, embryogenesis, tissue resorption, and in the ...
H, Nagase +6 more
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Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease
2021Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways.
Oskar, Zakiyanov +3 more
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Current Opinion in Biotechnology
Targeting metalloproteinases (MPs) has been the center of attention for developing therapeutics due to their contribution to a wide range of diseases, including cancer, cardiovascular, neurodegenerative disease, and preterm labor. Protein-based MP inhibitors offer higher stability and selectivity, which is critical for developing efficient therapeutics
Masoud Kalantar +3 more
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Targeting metalloproteinases (MPs) has been the center of attention for developing therapeutics due to their contribution to a wide range of diseases, including cancer, cardiovascular, neurodegenerative disease, and preterm labor. Protein-based MP inhibitors offer higher stability and selectivity, which is critical for developing efficient therapeutics
Masoud Kalantar +3 more
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Diseases of the Colon & Rectum, 1996
Colonic adenocarcinomas evolve through a multistep process from tubular adenomas to invasive adenocarcinomas. Matrix metalloproteinases (MMPs) have been implicated in proteolysis of basement membrane for initiation of metastatic cascade.By immunocytochemical staining, hyperplastic polyps, tubular adenomas, tubovillous adenomas, villous adenomas to ...
T, Tomita, K, Iwata
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Colonic adenocarcinomas evolve through a multistep process from tubular adenomas to invasive adenocarcinomas. Matrix metalloproteinases (MMPs) have been implicated in proteolysis of basement membrane for initiation of metastatic cascade.By immunocytochemical staining, hyperplastic polyps, tubular adenomas, tubovillous adenomas, villous adenomas to ...
T, Tomita, K, Iwata
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Tissue inhibitor of metalloproteinases-1 in breast cancer
Endocrine Related Cancer, 2005Whether patients diagnosed with primary breast cancer are offered adjuvant systemic therapy following surgical removal of the tumor is based on prognosis. Prognosis is estimated in every patient using established prognostic variables. Unfortunately, when using the currently available prognostic parameters a significant proportion of patients are over ...
Würtz, Sidse Ørnbjerg +6 more
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Archives of Biochemistry and Biophysics, 1987
Dissected embryonic chick limbs release neutral metalloproteinases during endochondral bone development. These enzymes degrade cartilage proteoglycan and gelatin in culture medium. We found the enzymes active in the medium conditioned by explants of the region adjacent to the bone marrow cavity (cavity-surround). These enzymes degrade proteoglycan (PG)
Y, Mikuni-Takagaki, Y S, Cheng
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Dissected embryonic chick limbs release neutral metalloproteinases during endochondral bone development. These enzymes degrade cartilage proteoglycan and gelatin in culture medium. We found the enzymes active in the medium conditioned by explants of the region adjacent to the bone marrow cavity (cavity-surround). These enzymes degrade proteoglycan (PG)
Y, Mikuni-Takagaki, Y S, Cheng
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Cardiovascular Pathology, 2006
Coxsackievirus B3 (CVB3) is the major causative agent of myocarditis in humans. In the mouse model, the inflammatory phase of myocarditis results in extensive damage to the heart and triggers profound extracellular matrix (ECM) remodeling, which may ultimately lead to dilated cardiomyopathy.
Caroline, Cheung +8 more
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Coxsackievirus B3 (CVB3) is the major causative agent of myocarditis in humans. In the mouse model, the inflammatory phase of myocarditis results in extensive damage to the heart and triggers profound extracellular matrix (ECM) remodeling, which may ultimately lead to dilated cardiomyopathy.
Caroline, Cheung +8 more
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