Results 221 to 230 of about 68,791 (257)
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Plastic and Reconstructive Surgery, 2003
Dupuytren's contracture is a fibroproliferative disorder characterized by progressive deposition of mature collagen fibers. In other fibrotic diseases affecting organs such as the liver, lung, heart, and skin, matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), play an important role.
Dietmar, Ulrich +2 more
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Dupuytren's contracture is a fibroproliferative disorder characterized by progressive deposition of mature collagen fibers. In other fibrotic diseases affecting organs such as the liver, lung, heart, and skin, matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), play an important role.
Dietmar, Ulrich +2 more
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Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease
2021Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways.
Oskar, Zakiyanov +3 more
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The Prostate, 1998
The balance between matrix metalloproteinases (MMP) and the tissue inhibitors of metalloproteinases (TIMP) has been seen as important during tumor invasion and progression. The determination of these components needs a special strategy of tissue preparation.
K, Jung +6 more
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The balance between matrix metalloproteinases (MMP) and the tissue inhibitors of metalloproteinases (TIMP) has been seen as important during tumor invasion and progression. The determination of these components needs a special strategy of tissue preparation.
K, Jung +6 more
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Journal of Surgical Oncology, 2010
AbstractBackground and ObjectivesMatrix metalloproteinases (MMPs) are one of the major classes of proteolytic enzymes involved in tumor invasion and metastasis, being inhibited by naturally occurring tissue inhibitors of metalloproteinases (TIMPs).
Ming, Zhang +4 more
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AbstractBackground and ObjectivesMatrix metalloproteinases (MMPs) are one of the major classes of proteolytic enzymes involved in tumor invasion and metastasis, being inhibited by naturally occurring tissue inhibitors of metalloproteinases (TIMPs).
Ming, Zhang +4 more
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Tissue Inhibitor of Metalloproteinase Expression
1998Invasion and metastasis are the most life threatening aspects of the oncogenic process. Present therapies, which focus mainly on disruption of growth and division of tumour cells, are of limited use against most highly malignant solid tumours, as they do not combat the invasive and metastatic characteristics of the tumour cells.
A. M. McElligott +2 more
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Frontiers in Bioscience, 2007
Together, the matrix metalloproteinases (MMPs) are capable of degrading every component of the extracellular matrix (ECM). Besides degradation of the ECM, MMPs release bioactive molecules from the matrix or cell surface and play important role in tissue repair after injury, development and in a number of pathologies including arthritis and cancer ...
Clark IM, Swingler TE, Young DA
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Together, the matrix metalloproteinases (MMPs) are capable of degrading every component of the extracellular matrix (ECM). Besides degradation of the ECM, MMPs release bioactive molecules from the matrix or cell surface and play important role in tissue repair after injury, development and in a number of pathologies including arthritis and cancer ...
Clark IM, Swingler TE, Young DA
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Cardiovascular Pathology, 2006
Coxsackievirus B3 (CVB3) is the major causative agent of myocarditis in humans. In the mouse model, the inflammatory phase of myocarditis results in extensive damage to the heart and triggers profound extracellular matrix (ECM) remodeling, which may ultimately lead to dilated cardiomyopathy.
Caroline, Cheung +8 more
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Coxsackievirus B3 (CVB3) is the major causative agent of myocarditis in humans. In the mouse model, the inflammatory phase of myocarditis results in extensive damage to the heart and triggers profound extracellular matrix (ECM) remodeling, which may ultimately lead to dilated cardiomyopathy.
Caroline, Cheung +8 more
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Diseases of the Colon & Rectum, 1996
Colonic adenocarcinomas evolve through a multistep process from tubular adenomas to invasive adenocarcinomas. Matrix metalloproteinases (MMPs) have been implicated in proteolysis of basement membrane for initiation of metastatic cascade.By immunocytochemical staining, hyperplastic polyps, tubular adenomas, tubovillous adenomas, villous adenomas to ...
T, Tomita, K, Iwata
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Colonic adenocarcinomas evolve through a multistep process from tubular adenomas to invasive adenocarcinomas. Matrix metalloproteinases (MMPs) have been implicated in proteolysis of basement membrane for initiation of metastatic cascade.By immunocytochemical staining, hyperplastic polyps, tubular adenomas, tubovillous adenomas, villous adenomas to ...
T, Tomita, K, Iwata
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Cancer research, 1993
Unregulated secretion of matrix metalloproteinases (MMPs) or their endogenous protein inhibitors (tissue inhibitor of metalloproteinases, TIMPs) has been implicated in tumor invasion and metastasis. Species of MMPs and TIMPs secreted by epithelial cultures of normal, benign, and malignant prostate were identified and their levels were compared ...
B L, Lokeshwar +3 more
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Unregulated secretion of matrix metalloproteinases (MMPs) or their endogenous protein inhibitors (tissue inhibitor of metalloproteinases, TIMPs) has been implicated in tumor invasion and metastasis. Species of MMPs and TIMPs secreted by epithelial cultures of normal, benign, and malignant prostate were identified and their levels were compared ...
B L, Lokeshwar +3 more
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Tissue Inhibitors of Metalloproteinases in Cancer
2002Our understanding of the biological function of tissue inhibitors of metalloproteinases (TIMP) has significantly evolved from an initial focus on the extracellular matrix (ECM) to a much broader function that includes a regulatory role on cell growth, survival and transformation. The bases for this larger role of TIMPs are several. 1.
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