Results 41 to 50 of about 166,094,829 (292)

Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology [PDF]

International Journal of Ophthalmology, 2017
There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with ...
Mahavir Singh, Suresh C Tyagi
doaj   +1 more source

Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Dilated cardiomyopathy (DCM) is a common cause of heart failure in adult and pediatric patients, but the underlying mechanism may vary in adults and children, with few studies conducted to date.
Sayantan Jana, Hao Zhang, Gary D. Lopaschuk, Darren H. Freed, Consolato Sergi, Paul F. Kantor, Gavin Y. Oudit, Zamaneh Kassiri   +7 more
doaj   +1 more source

The Significance of Matrix Metalloproteinases in Parasitic Infections Involving the Central Nervous System

Pathogens, 2013
Matrix metalloproteinases (MMPs) represent a large family of over twenty different secreted or membrane-bound endopeptidases, involved in many physiological (embryogenesis, precursor or stem cell mobilization, tissue remodeling during wound healing, etc.)
Fabrizio Bruschi, Barbara Pinto
doaj   +1 more source

Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells [PDF]

, 2007
MMP-9 (matrix metalloproteinase 9) plays a critical role in tumour progression. Although the biochemical properties of the secreted form of proMMP-9 are well characterized, little is known about the function and activity of cell surface-associated proMMP-
Mentele, Reinhard, Egea, Virginia, Jochum, Marianne, Ries, Christian, Zahler, Stefan, Nagase, Hideaki, Pitsch, Thomas   +6 more
core   +1 more source

Plasma matrix metalloproteinases in neonates having surgery for congenital heart disease

Heart International, 2009
During cardiopulmonary-bypass matrix-metalloproteinases released may contribute to ventricular dysfunction. This study was to determine plasma matrix-metalloproteinases in neonates after cardiopulmonary-bypass and their relation to post-operative course.
David B. Ross, Richard Schulz, Po-Yin Cheung, Ivan M. Rebeyka, Rhonda J. Rosychuk, John Dyck, Ari R. Joffe, Christina Schulz   +7 more
doaj   +1 more source

Correlation of TIMP1-MMP2/MMP9 Gene Expression Axis Changes with Treatment Efficacy and Survival of NSCLC Patients

Biomedicines, 2023
In the course of lung cancer, normal cells are transformed into cancerous ones, and changes occur in the microenvironment, including the extracellular matrix (ECM), which is not only a scaffold for cells, but also a reservoir of cytokines, chemokines and
Jacek Pietrzak, Agnieszka Wosiak, Dagmara Szmajda-Krygier, Rafał Świechowski, Mariusz Łochowski, Milena Pązik, Ewa Balcerczak   +6 more
doaj   +1 more source

Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors

Biochemical Society Symposia, 2003
The tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of the matrix metalloproteinases (MMPs), enzymes that play central roles in the degradation of extracellular matrix components. The balance between MMPs and TIMPs is important in the maintenance of tissues, and its disruption affects tissue homoeostasis.
Nagase, H, Brew, K
openaire   +3 more sources

The role of sinusoidal endothelial cells and TIMP1 in the regulation of fibrosis in a novel human liver 3D NASH model

Hepatology Communications
Background:. The prevalence of NAFLD is rapidly increasing. NAFLD can progress to NASH, fibrosis, cirrhosis, and HCC, which will soon become the main causes of liver transplantation.
Sander van Riet, Anais Julien, Andrea Atanasov, Åsa Nordling, Magnus Ingelman-Sundberg   +4 more
doaj   +1 more source

Unbalanced Metalloproteinase-9 and Tissue inhibitors of Metalloproteinases Ratio Predicts Hemorrhagic Transformation of Lesion in Ischemic Stroke Patients Treated with Thrombolysis: Results from the MAGIC Study

Frontiers in Neurology, 2015
Background Experimentally, metalloproteinases (MMPs) play a detrimental role related to severity of ischemic brain lesions. Both MMPs activity and function in tissues reflect the balance between MMPs and tissue inhibitors of metalloproteinases (TIMPs ...
Benedetta ePiccardi, Vanessa ePalumbo, Mascia eNesi, Patrizia eNencini, Anna Maria eGori, Betti eGiusti, Giovanni ePracucci, Paolina eTonelli, Eleonora eInnocenti, Alice eSereni, Elena eSticchi, Danilo eToni, Paolo eBovi, Mario eGuidotti, Maria Rosaria eTola, Domenico eConsoli, Giuseppe eMicieli, Rossana eTassi, Giovanni eOrlandi, Francesco ePerini, Norina eMarcello, Antonia eNucera, Francesca eMassaro, DeLodovici eMaria Luisa, Maria eSessa, Rosanna eAbbate, Domenico eInzitari, Domenico eInzitari   +27 more
doaj   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source