Results 21 to 30 of about 68,672 (258)

Engineered Sarafotoxins as Tissue Inhibitor of Metalloproteinases-like Matrix Metalloproteinase Inhibitors [PDF]

Journal of Biological Chemistry, 2007
The sarafotoxins and endothelins are approximately 25-residue peptides that spontaneously fold into a defined tertiary structure with specific pairing of four cysteines into two disulfide bonds. Their structures show an interesting topological similarity to the core of the metalloproteinase interaction sites of the tissue inhibitors of ...
Janelle L, Lauer-Fields, Mare, Cudic, Shuo, Wei, Frank, Mari, Gregg B, Fields, Keith, Brew   +5 more
openaire   +2 more sources

Inhibition of Tissue Matrix Metalloproteinases Interferes with Mycobacterium tuberculosis-Induced Granuloma Formation and Reduces Bacterial Load in a Human Lung Tissue Model

Frontiers in Microbiology, 2017
Granulomas are hallmarks of pulmonary tuberculosis (TB) and traditionally viewed as host-protective structures. However, recent evidence suggest that Mycobacterium tuberculosis (Mtb) uses its virulence factors to stimulate the formation of granuloma.
Venkata R. Parasa, Jagadeeswara R. Muvva, Jeronimo F. Rose, Clara Braian, Susanna Brighenti, Maria Lerm   +5 more
doaj   +1 more source

The activity of matrix metalloproteinases and the concentration of their tissue inhibitors in the blood serum of patients with type 2 diabetes mellitus, depending on the stage of compensation of the disease

Сибирский научный медицинский журнал, 2021
The aim of the study was to test the hypothesis on the possible reason for the decrease in the activity of matrix metalloproteinases (MMPs) as a consequence of the high concentration of their tissue inhibitors (TIMPs) in the blood serum of patients with ...
A. V. Zubova, A. R. Kolpakov, G. S. Russkikh, O. N. Poteryaeva   +3 more
doaj   +1 more source

Inactivation of tissue inhibitor of metalloproteinase‐1 by peroxynitrite [PDF]

FEBS Letters, 1996
Peroxynitrate (ONOO−) has recently been implicated in connective tissue destruction in vivo. We have studied the effect of ONOO− on the activity of tissue inhibitor of metalloproteinase‐1 (TIMP‐1) in vitro. The inactivation of TIMP‐1 by ONOO− was dose dependent with 50 μM ONOO− reducing the inhibitory activity of TIMP‐1 towards gelatinase‐A by 50 ...
Frears, Emma R., Zhang, Zhi, Blake, David R., O'Connell, James P., Winyard, Paul G.   +4 more
openaire   +2 more sources

The Effects of Botulinum Toxin A on Collagen Synthesis, Expression of MMP (matrix metalloproteinases)-1,2,9 and TIMP (tissue inhibitors of metalloproteinase)-1 in the Keloid Fibroblasts [PDF]

Archives of Aesthetic Plastic Surgery, 2013
Keloids are characterized by excessive extracelluar matrix (ECM) deposition such as collagen, fibronectin, elastin, and proteoglycans in the dermis. Recently, the use of botulinum toxin A (BTXA) in the treatment of keloids have had good results.
Tai Suk Roh, Jong Won Hong, Won Jai Lee, Han-su Yoo, Dae Hyun Lew, Young Seok Kim   +5 more
doaj   +1 more source

Matrix metalloproteinases in the process of invasion and metastasis of breast cancer [PDF]

Archive of Oncology, 2006
Metastatic cascade in malignant tumors, including breast cancer, starts with localized invasion of the host tissue. This process, requiring that tumor cells separate from each other, includes loss of homotypic and heterotypic cell adhesion and cell-cell ...
Konjević Gordana, Stanković Sandra
doaj   +1 more source

Tissue Inhibitor of Metalloproteinases-4. The road less traveled

Molecular Cancer, 2008
Tissue inhibitors of metalloproteinases (TIMPs) regulate diverse processes, including extracellular matrix (ECM) remodeling, and growth factors and their receptors' activities through the inhibition of matrix metalloproteinases (MMPs).
Ceballos Gisela, Pozo Luis, Melendez-Zajgla Jorge, Maldonado Vilma   +3 more
doaj   +1 more source

Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology [PDF]

International Journal of Ophthalmology, 2017
There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with ...
Mahavir Singh, Suresh C Tyagi
doaj   +1 more source

Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Dilated cardiomyopathy (DCM) is a common cause of heart failure in adult and pediatric patients, but the underlying mechanism may vary in adults and children, with few studies conducted to date.
Sayantan Jana, Hao Zhang, Gary D. Lopaschuk, Darren H. Freed, Consolato Sergi, Paul F. Kantor, Gavin Y. Oudit, Zamaneh Kassiri   +7 more
doaj   +1 more source

The Significance of Matrix Metalloproteinases in Parasitic Infections Involving the Central Nervous System

Pathogens, 2013
Matrix metalloproteinases (MMPs) represent a large family of over twenty different secreted or membrane-bound endopeptidases, involved in many physiological (embryogenesis, precursor or stem cell mobilization, tissue remodeling during wound healing, etc.)
Fabrizio Bruschi, Barbara Pinto
doaj   +1 more source