Results 191 to 200 of about 599,368 (371)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Catabolism of human tissue plasminogen activator in mice [PDF]

, 1985
HE Fuchs, H Jr Berger, SV Pizzo
openalex   +1 more source

Population Pharmacokinetic/Pharmacodynamic and Exposure–Response Modeling of Garadacimab in Healthy Volunteers and Patients With Hereditary Angioedema

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Hereditary angioedema (HAE) is a rare genetic disease that manifests as recurrent, unpredictable, and potentially life‐threatening attacks of angioedema. Garadacimab is a first‐in‐class, fully human, monoclonal antibody targeting activated factor XII (FXIIa) that is under clinical development for the long‐term prophylaxis of HAE attacks.
Ramon Garcia, Shen Cheng, Fiona Glassman, Ankur Sharma, Bernardo De Miguel‐Lillo, Matthew Wiens, Curtis Johnston, John‐Philip Lawo, Ingo Pragst, Jonathan French, Dan Polhamus, Partha Nandy   +11 more
wiley   +1 more source

FRACTIONATION OF PLASMINOGEN ACTIVATOR AND PROACTIVATOR IN TISSUE AND BLOOD BY GEL FILTRATION

, 1964
Akikazu Takada, Yumiko Takada, U Okamoto
openalex   +2 more sources

Multifunctional Co‐Delivery Systems with Downregulation of the Novel Target PIM1 in Macrophages to Ameliorate TF‐Mediated Coagulopathy in Sepsis

Small, EarlyView.
PIM1 is screened out and verified its correlation with sepsis‐induced coagulopathy by bioinformatic analysis and clinical research. Then a multifunctional co‐delivery system (MPDA@PEI@GM) is proposed for the co‐deliver of the PIM1 inhibitors SMI‐4a and small interfering RNA (siPIM1) to reduce PIM1 expression, which effectively inhibits the expression ...
Aiming Zhou, Jiejie Cai, Ying Wang, Rongrong Zhang, Jiang Tan, Chen Zhou, Shuang Luo, Qiuqi Gao, Yueyue Huang, Yihua Dong, Haiqing Song, Jingye Pan   +11 more
wiley   +1 more source

56. Experimental Study of Surgical Procedure upon Plasminogen Activator and Inhibitor in Brain Tissue of Subcellular Units and in Blood

, 1966
Yoshihiro Okada
openalex   +2 more sources

Differences between binding of one-chain and two-chain tissue plasminogen activators to non-cross-linked and cross-linked fibrin clots [PDF]

, 1989
S. Shaukat Husain, AA Hasan, AZ Budzynski   +2 more
openalex   +1 more source

Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury. [PDF]

, 2019
The goal of stem cell therapy for spinal cord injury (SCI) is to restore motor function without exacerbating pain. Induced pluripotent stem cells (iPSC) may be administered by autologous transplantation, avoiding immunologic challenges.
Brifault, Coralie, Campana, Wendy M, Gonias, Steven L, Jeziorski, Jacob J, Kim, John H, Kwon, HyoJun, Mesci, Pinar, Muotri, Alysson R, Nasamran, Chanond, Ohtori, Seiji, Shiga, Akina, Shiga, Yasuhiro   +11 more
core  

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Associations Between Measures of Structural Racism and Receipt of Acute Ischemic Stroke Interventions in the United States

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Structural racism and rural/urban differences in stroke care affect care delivery and outcomes. We explored the interplay among structural racism, urbanity, and intravenous thrombolysis (tissue plasminogen activator) and endovascular ...
Amol M. Mehta, Sai P. Polineni, Praneet Polineni, Mandip S. Dhamoon   +3 more
doaj   +1 more source