Results 211 to 220 of about 160,265 (347)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Serum tissue plasminogen activator after cycling with blood flow restriction. [PDF]

Vasc Biol
Landers JB, Allen M, Oladele I, Lowe L, Ali N, Rainey J, Fletcher J, Landers K.   +7 more
europepmc   +1 more source

Tissue Plasminogen Activator (tPA) Use in Persistent Loculated Ascites. [PDF]

Cureus
Ali KM, Molloy R, Friedman A, Srikureja W, Bent C, Garrison RC.   +5 more
europepmc   +1 more source

Iron enhances reactive oxygen species generation and initiates neutrophil extracellular traps formation on the endothelium to exacerbate stroke

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Under hypoxic conditions, iron from red blood cells and injured tissues is taken up by endothelial cells. During reoxygenation, this iron is exported via Fpn1, promoting NETs formation by enhancing ROS production through the Fenton reaction, ultimately exacerbating cerebral injury.
Weijian Fan, Zebin Fang, Yuxiang Weng, Tianxiang Zhan, Kaiyuan Huang, Jianwei Pan, Renya Zhan   +6 more
wiley   +1 more source

Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator-Induced Brain Hemorrhagic Transformation After Ischemic Stroke. [PDF]

CNS Neurosci Ther
Xie G, Jiang G, Huang L, Sun S, Li X, Wu B, Wang H, Zhang Z, Ye K, Yu Y, Xiong J.   +10 more
europepmc   +1 more source

Differentiation-responsive elements in the 5' region of the mouse tissue plasminogen activator gene confer two-stage regulation by retinoic acid and cyclic AMP in teratocarcinoma cells.

, 1989
Richard J. Rickles, Andrew L. Darrow, Sidney Strickland   +2 more
openalex   +1 more source

Oscillating gradient spin echo diffusion time effects implicate variations in neurite beading for the heterogeneous reduced diffusion in human acute ischemic stroke lesions

Magnetic Resonance in Medicine, Volume 94, Issue 5, Page 2158-2172, November 2025.
Abstract Purpose Monte Carlo simulations and short diffusion time measurements have suggested neurite beading and swelling as the underlying mechanism of reduced diffusion in acute stroke, although the observed diffusion time dependence is often heterogeneous and not yet fully understood.
Mi Zhou, Rob Stobbe, Matthew Budde, Brian Buck, Mahesh Kate, Mar Lloret, Paige Fairall, Ken Butcher, Ashfaq Shuaib, Derek Emery, Thorsten Feiweier, Christian Beaulieu   +11 more
wiley   +1 more source

Endovascular thrombectomy versus intravenous tissue plasminogen activator for vertebrobasilar stroke treatment: insights from the national inpatient sample. [PDF]

Front Neurol
Saha R, Nepal G, Solanki D, Shaheen A, Al-Salihi MM, Dalal SS, Roy A.   +6 more
europepmc   +1 more source

A tissue-type plasminogen activator mutant with prolonged clearance in vivo. Effect of removal of the growth factor domain.

, 1988
Molly Browne, J.E. Carey, C.G. Chapman, A. W. R. TYRRELL, Claire Entwisle, G. M. Lawrence, B. Reavy, Ian B. Dodd, A.F. Esmail, J.H. Robinson   +9 more
openalex   +1 more source

Granulocyte Transfusions in Pediatric Hemato‐Oncology: Neutrophil Response and CRP Kinetics

Pediatric Blood &Cancer, Volume 72, Issue 11, November 2025.
ABSTRACT Background Granulocyte transfusions (GTXs) are used in neutropenic pediatric hemato‐oncology patients with infections unresponsive to antimicrobial therapy, but their clinical benefit remains uncertain. Methods We retrospectively reviewed all pediatric patients who received GTXs between 2013 and 2023 at a tertiary medical center.
Aviv Sever, Ron Rabinowicz, Shlomit Barzilai‐Birenboim, Salvador Fisher, Ronit Goldman Levi, Assaf Yanir, Jerry Stein, Efraim Bilavsky, Joanne Yacobovich, Vered Yahalom   +9 more
wiley   +1 more source