Individual globular domains and domain unfolding visualized in overstretched titin molecules with atomic force microscopy. [PDF]
PLoS ONE, 2014 Titin is a giant elastomeric protein responsible for the generation of passive muscle force. Mechanical force unfolds titin's globular domains, but the exact structure of the overstretched titin molecule is not known.
Zsolt Mártonfalvi, Miklós Kellermayer
doaj +4 more sources
A “Force Buffer” protecting immunoglobulin titin. [PDF]
Angewandte Chemie - International Edition, 2010 The adventures of titin: in vertebrates, titin filaments control the extendibility of the muscle sarcomere. The titin immunoglobulin 27 unfolds through an intermediate (see structure; arrow: hydrogen bonds ruptured to reach intermediate) that it is ...
Muller, Daniel J +22 more
core +4 more sources
Titin is a Target of Matrix Metalloproteinase-2 [PDF]
Circulation, 2010 Background— Titin is the largest mammalian (≈3000 to 4000 kDa) and myofilament protein that acts as a molecular spring in the cardiac sarcomere and determines systolic and diastolic function.
Mohammad A.M. Ali +5 more
core +3 more sources
Titin‐based mechanosensing modulates muscle hypertrophy [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2018 Background Titin is an elastic sarcomeric filament that has been proposed to play a key role in mechanosensing and trophicity of muscle. However, evidence for this proposal is scarce due to the lack of appropriate experimental models to directly test the
Robbert van derPijl +6 more
doaj +2 more sources
C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness [PDF]
JCI Insight, 2020 Heart failure is often accompanied by titin-dependent myocardial stiffness. Phosphorylation of titin by cGMP-dependent protein kinase I (PKGI) increases cardiomyocyte distensibility.
Konstanze Michel +11 more
doaj +2 more sources
Urinary Titin Is Increased in Patients After Cardiac Surgery [PDF]
Frontiers in Cardiovascular Medicine, 2019 Background: Few non-invasive biomarkers have been used to detect myocardial injury in patients with heart diseases. Recently, the N-terminal fragment (N-titin) of titin, a giant sarcomeric protein, which is involved in muscular passive tension and ...
Jun Tanihata +5 more
doaj +3 more sources
Force generation by titin folding [PDF]
Protein Science, 2017 AbstractTitin is a giant protein that provides elasticity to muscle. As the sarcomere is stretched, titin extends hierarchically according to the mechanics of its segments. Whether titin's globular domains unfold during this process and how such unfolded domains might contribute to muscle contractility are strongly debated.
Mártonfalvi, Zsolt +4 more
openaire +7 more sources
Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation [PDF]
, 2022 Aims: Dilated cardiomyopathy (DCM) is associated with mutations in many genes encoding sarcomere proteins. Truncating mutations in the titin gene TTN are the most frequent.
Maya Guglin (5773304) +11 more
core +1 more source
Pengaruh Prone positioning Terhadap Respiratory Rate dan Saturasi Oksigen Pada Bayi Gawat Napas (Respiratory Distress Syndrome ) di Ruang NICU RSUD Gunung Jati Cirebon [PDF]
, 2021 : THE EFFECT OF PRONE POSITIONING ON RESPIRATORY RATE AND OXYGEN SATURATION IN INFANTS WITH RESPIRATORY DISTRESS SYNDROME IN NEONATUS INTENSIVE CARE UNIT AT GUNUNG JATI HOSPITAL CIREBON.
Supriatin, Titin, Nurhayani, Yani
core +1 more source
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations [PDF]
, 2021 Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated cardiomyopathy (DCM), but the underlying pathomechanisms are unclear and disease management remains uncertain. Truncated titin proteins have not yet been considered
Gärtner, A. +27 more
core +1 more source