Results 31 to 40 of about 22,741 (230)
Structural insights into the basis and evolution of interactions in multi-subunit protein assemblies. tryptophan synthase and titin FNIII-repeats [PDF]
, 2008 Cellular processes benefit from evolutionary shaping when optimized protein-protein interactions result in enhanced functionality. In fact, most cellular proteins are tightly embedded into biological networks that function following a modularity ...
Bucher, Rainer Michael
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Detection and quantification of the giant protein titin by SDS-agarose gel electrophoresis
MethodsX, 2017 Titin, a giant sarcomeric protein, is involved in the generation of passive tension during muscle contraction, assembly and stability of the sarcomere in striated muscles. Titin gene produces numerous titin protein isoforms with different sizes (∼3–4 MDa)
Chaoqun Zhu, Wei Guo
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, 2022 Nucleophosmin (NPM1) interacts with other scaffolding proteins to bring together two or more proteins in a relatively stable configuration. This is done to maintain the liquid-like matrix of the nucleolus.
Ballinger, Kenzie, Warner, Lisa
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The Journal of Cell Biology, 2000 Previously, we reported that chromosomes contain a giant filamentous protein, which we identified as titin, a component of muscle sarcomeres. Here, we report the sequence of the entire titin gene in Drosophila melanogaster, D-Titin, and show that it encodes a two-megadalton protein with significant colinear homology to the NH2-terminal half of ...
Cristina Machado, Deborah J. Andrew
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Inferring the diameter of a biopolymer from its stretching response [PDF]
, 2005 We investigate the stretching response of a thick polymer model by means of extensive stochastic simulations. The computational results are synthesized in an analytic expression that characterizes how the force versus elongation curve depends on the ...
MICHELETTI C +6 more
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Modulation of Titin-Based Stiffness by Disulfide Bonding in the Cardiac Titin N2-B Unique Sequence [PDF]
, 2009 The giant protein titin is responsible for the elasticity of nonactivated muscle sarcomeres. Titin-based passive stiffness in myocardium is modulated by titin-isoform switching and protein-kinase (PK)A- or PKG-dependent titin phosphorylation.
Garcia-Manes, Sergi +6 more
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Titin (Visco-) Elasticity in Skeletal Muscle Myofibrils [PDF]
, 2014 Titin is the third most abundant protein in sarcomeres and fulfills a number of mechanical and signaling functions. Specifically, titin is responsible for most of the passive forces in sarcomeres and the passive visco-elastic behaviour of myofibrils and ...
W. Herzog +3 more
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Of cilia, titin, and neurosteroids [PDF]
Journal of General Physiology, 2014 This month’s installment of Generally Physiological discusses a calcium compartment in primary cilia, how changes in titin splicing can lead to skeletal muscle myopathy, and a negative feedback loop whereby a neurosteroid protects against hyperactivation of type-1 cannabinoid (CB1) receptors.
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Gigantic Business Titin Properties and Function Through Thick and Thin [PDF]
, 2014 The giant protein titin forms a unique filament network in cardiomyocytes, which engages in both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a major human disease gene.
Linke, W.A. +3 more
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Circulation Research, 2009 See related articles, pages 631–638 Diastolic performance is regulated by net myocardial stiffness, which is determined by the mechanosensitive protein network comprised of extracellular proteins such as collagen, intracellular sarcomeric proteins, and cell surface integrins.
S. Hinan Ahmed, Merry L. Lindsey
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