Results 41 to 50 of about 26,024 (216)
Time-Dependent Voronoi Analysis of Amino Acid Side-Chain Packing in Simulations. [PDF]
J Comput ChemProtein volume fluctuation is largely driven by loosely packed amino acid side chains while the backbone is comparatively restrained. We present a Voronoi‐based framework for quantifying and tracking local side‐chain volume and reorganization of neighbors. Paired snapshots show Voronoi tessellations for a side chain during molecular dynamics simulation
Bettencourt SB, Hwang W.
europepmc +2 more sources
European Journal of Histochemistry, 2009 Titin, a sarcomeric giant protein, plays crucial roles in muscle assembly, elasticity and stability. Little is known about titin adaptation to endurance exercise.
M Bellafiore +6 more
doaj +1 more source
Circulation Research, 2009 See related articles, pages 631–638 Diastolic performance is regulated by net myocardial stiffness, which is determined by the mechanosensitive protein network comprised of extracellular proteins such as collagen, intracellular sarcomeric proteins, and cell surface integrins.
S. Hinan Ahmed, Merry L. Lindsey
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Attenuated titin protein expression is associated with advanced stages of ovarian cancer
Molecular Therapy: OncologyThis study explores the role of titin, a giant muscle protein, in the progression of epithelial ovarian cancer (EOC). We examined titin levels in tissues and sera from EOC patients across stages I–IV and in chemoresistant EOC cells.
Harvey Sharma +10 more
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Secondary and Tertiary Structure Elasticity of Titin Z1Z2 and a Titin Chain Model [PDF]
Biophysical Journal, 2007 The giant protein titin, which is responsible for passive elasticity in muscle fibers, is built from approximately 300 regular immunoglobulin-like (Ig) domains and FN-III repeats. While the soft elasticity derived from its entropic regions, as well as the stiff mechanical resistance derived from the unfolding of the secondary structure elements of Ig ...
Lee, Eric H. +3 more
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Advanced Materials, EarlyView.Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn +17 more
wiley +1 more source
Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
, 2022 Nucleophosmin (NPM1) interacts with other scaffolding proteins to bring together two or more proteins in a relatively stable configuration. This is done to maintain the liquid-like matrix of the nucleolus.
Ballinger, Kenzie, Warner, Lisa
core
Advanced Science, EarlyView.Standard cell culture supports were functionalized by laser‐structuring to generate advanced topographies tailored to skeletal muscle tissue. The physicochemical modifications of the polymeric surfaces and their interactions with cells were thoroughly investigated, confirming both safety and effectiveness in guiding muscle cell organization.
Lucas Duvert +10 more
wiley +1 more source
Nature Communications, 2018 Titin regulates myocyte stiffness through uncoiling and unfolding but these two processes cannot fully explain its elasticity. Here, the authors use atomic force microscopy to study the properties of titin disulfide bonds, showing that disulfide ...
David Giganti +4 more
doaj +1 more source