Results 41 to 50 of about 22,741 (230)
Titin Gene and Protein Functions in Passive and Active Muscle [PDF]
, 2018 The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein titin, which is a scaffolding filament, signaling platform, and provider of passive tension and elasticity in myocytes.
Wolfgang A. Linke, Linke, Wolfgang A.
core +1 more source
Attenuated titin protein expression is associated with advanced stages of ovarian cancer
Molecular Therapy: OncologyThis study explores the role of titin, a giant muscle protein, in the progression of epithelial ovarian cancer (EOC). We examined titin levels in tissues and sera from EOC patients across stages I–IV and in chemoresistant EOC cells.
Harvey Sharma +10 more
doaj +1 more source
Secondary and Tertiary Structure Elasticity of Titin Z1Z2 and a Titin Chain Model [PDF]
Biophysical Journal, 2007 The giant protein titin, which is responsible for passive elasticity in muscle fibers, is built from approximately 300 regular immunoglobulin-like (Ig) domains and FN-III repeats. While the soft elasticity derived from its entropic regions, as well as the stiff mechanical resistance derived from the unfolding of the secondary structure elements of Ig ...
Lee, Eric H. +3 more
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European Journal of Histochemistry, 2009 Titin, a sarcomeric giant protein, plays crucial roles in muscle assembly, elasticity and stability. Little is known about titin adaptation to endurance exercise.
M Bellafiore +6 more
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Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source
Nature Communications, 2018 Titin regulates myocyte stiffness through uncoiling and unfolding but these two processes cannot fully explain its elasticity. Here, the authors use atomic force microscopy to study the properties of titin disulfide bonds, showing that disulfide ...
David Giganti +4 more
doaj +1 more source
Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation
Advanced Science, EarlyView.A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou +12 more
wiley +1 more source
Folded globular domains in titin. [PDF]
, 2014 a–c. Examples of high-magnification AFM images in which ellipsoidal, globular structures can be identified along the contour of the titin molecule. d. Example of a topographical height profile along the axis of titin. e. Distribution of distance measured
Zsolt Mártonfalvi (511022) +1 more
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Animal Models and Experimental Medicine, 2022 The mdx mouse is a model of Duchenne muscular dystrophy (DMD), a fatal progressive muscle wasting disease caused by dystrophin deficiency, and is used most widely in preclinical studies.
Taku Shirakawa +10 more
doaj +1 more source
Cardiac Titin and Heart Disease [PDF]
Journal of Cardiovascular Pharmacology, 2014 The giant sarcomeric protein titin is a key determinant of myocardial passive stiffness and stress-sensitive signaling. Titin stiffness is modulated by isoform variation, phosphorylation by protein kinases, and, possibly, oxidative stress through disulfide bond formation. Titin has also emerged as an important human disease gene.
Martin M, LeWinter, Henk L, Granzier
openaire +2 more sources