Results 61 to 70 of about 22,741 (230)

Titin contribution to active muscle [PDF]

, 2021
The aim of this dissertation is to compare the traditional ‘muscle as motor’ viewpoint to the alternative viewpoint ‘muscle as composite material’. We make three parts to achieve the aim.
Jeong, Siwoo
core  

Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker

Journal of Translational Medicine, 2012
Background Titin is a muscle-specific protein found in cardiac and skeletal muscles which is responsible for restoring passive tension. Levels and functioning of titin have been shown to be affected by cardiac damage.
Vassiliadis Efstathios, Rasmussen Lars M, Byrjalsen Inger, Larsen Dorthe, Chaturvedi Rajiv, Hosbond Susanne, Saabye Lotte, Diederichsen Axel CP, Genovese Federica, Duffin Kevin L, Zheng Qinlong, Chen Xiaoliang, Leeming Diana J, Christiansen Claus, Karsdal Morten A   +14 more
doaj   +1 more source

Topology of interaction between titin and myosin thick filaments. [PDF]

, 2018
Titin is a giant protein spanning between the Z- and M-lines of the sarcomere. In the A-band titin is associated with the myosin thick filament. It has been speculated that titin may serve as a blueprint for thick-filament formation due to the super ...
Zsombor Papp, Sziklai Dominik, Lakatos, Eszter, Decker, Brennan, Kellermayer Miklós, Sziklai, Dominik, Mártonfalvi, Zsolt, Eszter Lakatos, Brennen Decker, Mártonfalvi Zsolt, Miklós Kellermayer, Brennan Decker, Lakatos Eszter, Kellermayer, Miklós, Papp, Zsombor, Papp Zsombor, Dominik Sziklai, Zsolt Mártonfalvi   +17 more
core   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Tight in Titin [PDF]

Structure, 2006
The mechanics of a protein joint, gluing two elastic titin molecules together in muscle, are explored using computer simulation in this issue of Structure by Lee et al. (2006). Maybe the glue itself also has another, more subtle, sensory role?
openaire   +1 more source

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, EarlyView.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

Cytoskeleton: Titin as a scaffold and spring [PDF]

, 1996
The complete sequence of the giant muscle protein titin has been determined. It provides further insight into how titin may act both as a scaffold and a spring to specify and maintain muscle ...
Trinick, John
core   +1 more source

Myasthenia Gravis and Thymoma

Muscle &Nerve, EarlyView.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

Emulating Titin by a Multidomain DNA Structure [PDF]

, 2022
Titin, a giant protein containing multiple tandem domains, is essential in maintaining the superior mechanical performance of muscle. The consecutive and reversible unfolding and refolding of the domains are crucial for titin to serve as a modular spring.
Nanpu Cao (11919006), Zhou Nie, Chengde Mao, Lu Qian (78994), Shuxun Cui (1588276), Wanhao Cai, Chengde Mao (5315), Lu Qian, Zhou Nie (1517275), Wanhao Cai (6816800), Nanpu Cao, Shuxun Cui   +11 more
core   +1 more source

A New Paradigm for Muscle Contraction

Frontiers in Physiology, 2015
For the past 60 years, muscle contraction had been thought to be governed exclusively by the contractile filaments, actin and myosin. This thinking explained most observations for concentric and isometric, but not for eccentric muscle contractions.
Walter eHerzog, Krysta ePowers, Kaleena eJohnston, Michael eDuVall   +3 more
doaj   +1 more source