Results 81 to 90 of about 26,024 (216)

Myasthenia Gravis and Thymoma

Muscle &Nerve, Volume 74, Issue 4, Page 1156-1173, October 2026.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

Deleting full length titin versus the titin M-band region leads to differential mechanosignaling and cardiac phenotypes

, 2019
BACKGROUND: Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease.
Gotthardt, M., Fink, C., Radke, M.H., Granzier, H.L., Polack, C., Methawasin, M.   +5 more
core   +1 more source

Titin is a new factor regulating arterial stiffness through vascular smooth muscle cell tone in male rats

Physiological Reports
Arterial stiffness is a robust predictor of cardiovascular disease and mortality. As such, there is substantial interest in uncovering its causal factors for the development of targeted treatments to regulate arterial stiffness. The elastic protein titin
Chaoqun Zhu, Terrance Bishop, Zachery R. Gregorich, Wei Guo   +3 more
doaj   +1 more source

Beyond BMI: Genome‐Wide Associations of Visceral Fat, Fat Mass, and Fat‐Free Mass in Eastern Asian Populations

Obesity, Volume 34, Issue 10, Page 1967-1978, October 2026.
ABSTRACT Objective BMI is widely used to define obesity and may not capture heterogeneity in body fat distribution. Genetic studies of obesity have largely focused on BMI but not visceral fat and fat‐free mass, which is particularly limited in East Asian populations.
Hsin‐Ming Lu, Shun‐Jen Chang, Kuei‐Hau Luo, Yun‐Shiuan Chuang, Fu‐Wen Liang, Hung‐Yi Chuang   +5 more
wiley   +1 more source

Studies on the interaction between titin and myosin [PDF]

, 1992
This study examines the interaction of titin and mysoin. In order to analyze the domains of myosin contributing to the binding for titin, we conducted a solid phase binding assay.
Chung-Jiuan Jeng, Mu-Chien Sun, Wang, Seu-Mei   +2 more
core  

Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function

Acta Neuropathologica Communications, 2017
Summary Myopathies encompass a wide variety of acquired and hereditary disorders. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties.
Andreas Unger, Lisa Beckendorf, Pierre Böhme, Rudolf Kley, Marion von Frieling-Salewsky, Hanns Lochmüller, Rolf Schröder, Dieter O. Fürst, Matthias Vorgerd, Wolfgang A. Linke   +9 more
doaj   +1 more source

Compliant Titin Isoform Content Is Reduced in Left Ventricles of Sedentary Versus Active Rats

Frontiers in Physiology, 2020
A sedentary lifestyle is associated with increased cardiovascular risk factors and reduced cardiac compliance when compared to a lifestyle that includes exercise training.
Charles S. Chung, Mark A. Hiske, Arjun Chadha, Patrick J. Mueller   +3 more
doaj   +1 more source

Topology of interaction between titin and myosin thick filaments.

, 2018
Titin is a giant protein spanning between the Z- and M-lines of the sarcomere. In the A-band titin is associated with the myosin thick filament. It has been speculated that titin may serve as a blueprint for thick-filament formation due to the super ...
Zsombor Papp, Sziklai Dominik, Lakatos, Eszter, Decker, Brennan, Kellermayer Miklós, Sziklai, Dominik, Mártonfalvi, Zsolt, Eszter Lakatos, Brennen Decker, Mártonfalvi Zsolt, Miklós Kellermayer, Brennan Decker, Lakatos Eszter, Kellermayer, Miklós, Papp, Zsombor, Papp Zsombor, Dominik Sziklai, Zsolt Mártonfalvi   +17 more
core   +1 more source

Understanding the functions of titin and nebulin [PDF]

FEBS Letters, 1992
Individual molecules of the giant muscle proteins titin and nebulin span large distances in the sarcomere. Approximately one‐third of the titin molecule forms elastic filaments linking the ends of thick filaments to the Z‐line. The remainder of the molecule is probably bound to the thick filament where it may regulate assembly of myosin and the other ...
openaire   +2 more sources

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, Volume 13, Issue 50, 7 September 2026.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source