Results 91 to 100 of about 26,024 (216)
, 2014 Diabetes mellitus adalah suatu sindroma gangguan metabolisme dengan hiperglikemia yang tidak semestinya sebagai akibat suatu defisiensi sekresi insulin atau berkurangnya efektifitas biologis dari insulin atau keduanya.
Titin Nur Farida, 062210101057
core
Folded globular domains in titin.
, 2014 a–c. Examples of high-magnification AFM images in which ellipsoidal, globular structures can be identified along the contour of the titin molecule. d. Example of a topographical height profile along the axis of titin. e. Distribution of distance measured
Zsolt Mártonfalvi (511022) +1 more
core +1 more source
Cell Division, 2012 Background Previously we have reported on the development of a new mouse anti-titin monoclonal antibody, named MAb Titl 5 H1.1, using the synthetic peptide N-AVNKYGIGEPLESDSVVAK-C which corresponds to an amino acid sequence in the A-region of the titin ...
Mikelsaar Aavo-Valdur +6 more
doaj +1 more source
Biochemical and Mechanical Investigation of Cardiac Titin Isoforms [PDF]
, 2008 SUMMARY Background: Titin is a giant elastic protein of muscle sarcomeres. Titin molecules link the Z-disk with the M-line and have structural, elastic and signaling functions in myocytes.
Neagoe, Ciprian
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Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations
Frontiers in NeurologyObjectiveThis study aimed to explore autoantibody clusters and their correlations with clinical features in 644 myasthenia gravis (MG) patients.MethodsMedical records of 664 MG patients were reviewed. Five autoantibodies (AChR, MuSK, titin, RyR, and LRP4)
Xupeng Sun +9 more
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Frontiers in Physiology, 2016 Titin is a giant scaffold protein with multiple functions in striated muscle physiology. Due to the elastic I-band domains and the filament-like integration in the half-sarcomere titin is an important factor for sarcomere assembly and serves as an ...
Martina eKrüger, Sebastian eKötter
doaj +1 more source
The role of titin in muscular disorders
Annals of Medicine, 2003 Titin, the biggest single (poly) peptide found in humans, and throughout nature so far, was long considered as a good candidate for inherited muscle diseases. However, disease-causing defects were not known until recently, when this central sarcomeric protein was associated with human skeletal tibial muscular dystrophy (TMD/LGMD2J), dilated ...
J Peter V, Hackman +2 more
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Frontiers in Physiology, 2016 Titin is a giant protein spanning from the Z-disk to the M-band of the cardiac sarcomere. In the I-band titin acts as a molecular spring, contributing to passive mechanical characteristics of the myocardium throughout a heartbeat.
Hannah C. Pulcastro +6 more
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Acute exercise modifies titin phosphorylation and increases cardiac myofilament stiffness
Frontiers in Physiology, 2014 Titin-based myofilament stiffness is largely modulated by phosphorylation of its elastic I-band regions N2-Bus (decreases passive stiffness, PT) and PEVK (increases PT). Here, we tested the hypothesis that acute exercise changes titin phosphorylation and
Anna Eliane Müller +6 more
doaj +1 more source
The Journal of Cell Biology, 2002 ![Graphic][1] Sarcomere thick filaments (white) are disrupted by inhibition of titin–MURF-1 binding (right). The sarcomere is more than a complicated piece of structural machinery. According to new results by McElhinny et al.
openaire +2 more sources